Avodart and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avodart (dutasteride) and Methotrexate sodium (methotrexate sodium). Common drug interactions include rectal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Avodart and Methotrexate sodium. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Avodart?

Avodart has active ingredients of dutasteride. It is often used in prostate examination abnormal. eHealthMe is studying from 16,428 Avodart users. Check the latest studies of Avodart.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.



On Jul, 07, 2026

15 people who take Avodart and Methotrexate sodium together, and have interactions are studied.

Avodart and Methotrexate sodium drug interactions.

What are the common drug interactions of Avodart and Methotrexate Sodium, by gender? *:

female:

n/a

male:

  1. Rectal haemorrhage (bleeding from anus)
  2. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  3. Pleural effusion (water on the lungs)
  4. Pneumonia
  5. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  6. Cardiac failure
  7. Infection
  8. Mucosal inflammation (infection of mucous membrane)
  9. Neutropenia (an abnormally low number of neutrophils)
  10. Arthropathy

What are the common drug interactions of Avodart and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Rectal haemorrhage (bleeding from anus)
  2. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  3. Pleural effusion (water on the lungs)
  4. Pneumonia
  5. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  6. Cardiac failure
  7. Infection
  8. Mucosal inflammation (infection of mucous membrane)
  9. Neutropenia (an abnormally low number of neutrophils)
  10. Arthropathy

What are the existing conditions these people have? *

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 20.00%
  2. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 13.33%
  3. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 13.33%
  4. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 13.33%
  5. Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 6.67%
  6. Febrile Bone Marrow Aplasia (bone marrow greatly decreases or stops production of blood cells): 1 person, 6.67%
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 6.67%
  8. Bone Disorder: 1 person, 6.67%
  9. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.67%
  10. Hypouricaemia (level of uric acid in the blood that is abnormally high): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Avodart and Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Avodart:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methotrexate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Avodart and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methotrexate sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on dutasteride and methotrexate sodium (the active ingredients of Avodart and Methotrexate sodium, respectively), and Avodart and Methotrexate sodium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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