Avonex and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avonex (interferon beta 1a) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include knee arthroplasty among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Avonex and Excedrin. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Avonex?

Avonex has active ingredients of interferon beta 1a. It is often used in multiple sclerosis. eHealthMe is studying from 198,544 Avonex users. Check the latest studies of Avonex.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 19, 2026

97 people who take Avonex and Excedrin together, and have interactions are studied.

What are the common drug interactions of Avonex and Excedrin, by gender? *:

female:

Knee arthroplasty
Ligament sprain (ligament stretched)
Limb discomfort (discomfort in leg)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mobility decreased (ability to move is reduced)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Osteoporosis (bones weak and more likely to break)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

male:

Asthenia (weakness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Abnormal dreams
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blood urine present
Cataract (clouding of the lens inside the eye)
Chills (felling of cold)
Dehydration (dryness resulting from the removal of water)
Drug abuse
Fall

What are the common drug interactions of Avonex and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Apathy
Asthenia (weakness)
Chills (felling of cold)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dizziness postural
Injection site pain
Injection site pruritus (severe itching at injection site)
Nausea (feeling of having an urge to vomit)

30-39:

Influenza like illness
Pyrexia (fever)
Drug hypersensitivity
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Atelectasis (partial or complete collapse of the lung)
Blood bicarbonate decreased
Blood chloride increased
Blood glucose decreased
Blood glucose increased
Blood ph increased

40-49:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Body temperature increased
Breast cancer
Delirium (wild excitement)
Dizziness exertional
Fall
Hypotension (abnormally low blood pressure)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Brain stem infarction (brainstem stroke)
Breast cancer
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Depression
Hot flush (sudden feelings of heat)
Thyroid gland cancer
Allergy to animal
Animal scratch

60+:

Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Faeces hard
Hypotension (abnormally low blood pressure)
Visual impairment
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Injury
Pain in extremity
Anxiety

What are the existing conditions these people have? *

Pain: 8 people, 8.25%
Depression: 7 people, 7.22%
High Blood Pressure: 6 people, 6.19%

* Approximation only. Some reports may have incomplete information.

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