Avonex and Tofranil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avonex (interferon beta 1a) and Tofranil (imipramine hydrochloride). Common drug interactions include memory impairment among females and carcinoid tumour of the stomach among males.

The phase IV clinical study analyzes what interactions people have when they take Avonex and Tofranil. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Avonex?

Avonex has active ingredients of interferon beta 1a. It is often used in multiple sclerosis. eHealthMe is studying from 198,544 Avonex users. Check the latest studies of Avonex.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

On Jul, 26, 2026

22 people who take Avonex and Tofranil together, and have interactions are studied.

What are the common drug interactions of Avonex and Tofranil, by gender? *:

female:

Memory impairment
Insomnia (sleeplessness)
Alopecia (absence of hair from areas of the body)
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Balance disorder
Blood glucose increased
Confusional state
Corneal ulcer
Drug ineffective

male:

Carcinoid tumour of the stomach
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrolithiasis (calculi in the kidneys)
Pneumonia
Sinusitis (inflammation of sinus)
Vomiting

What are the common drug interactions of Avonex and Tofranil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypersensitivity
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Ankle fracture
Balance disorder
Fall
Head injury
Injection site pain
Muscle spasms (muscle contraction)
Pregnancy
Tremor (trembling or shaking movements in one or more parts of your body)
Drug exposure during pregnancy

50-59:

Memory impairment
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Corneal ulcer
Dysstasia (difficulty in standing)
Haemorrhage (bleeding)
Muscular weakness (muscle weakness)
Osteoporosis (bones weak and more likely to break)
Uhthoff's phenomenon (heat intolerance)
Urinary tract infection

60+:

Carcinoid tumour of the stomach
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrolithiasis (calculi in the kidneys)
Pneumonia
Sinusitis (inflammation of sinus)
Vomiting

* Approximation only. Some reports may have incomplete information.

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