Axid and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Axid (nizatidine) and Rapamune (sirolimus). Common drug interactions include mental status changes among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Axid and Rapamune. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Axid?

Axid has active ingredients of nizatidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 2,980 Axid users. Check the latest studies of Axid.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 13, 2026

21 people who take Axid and Rapamune together, and have interactions are studied.

What are the common drug interactions of Axid and Rapamune, by gender? *:

female:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nystagmus (a condition of involuntary eye movement)
Staphylococcal infection (an infection with staphylococcus bacteria)
Abscess bacterial (collection of pus caused by bacteria)
Bacterial infection
Blood chloride increased
Blood creatine phosphokinase mb
Blood glucose increased
Blood phosphorus decreased
Blood pressure systolic increased

male:

Nausea (feeling of having an urge to vomit)
Ataxia (loss of full control of bodily movements)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Escherichia sepsis (bacterial infection by escherichia coli)
Fall
Glycosuria present
Haemoglobin decreased
Haemolytic anaemia (anaemia due to haemolysis)
Hyperkalaemia (damage to or disease of the kidney)
Hyporeflexia (a condition of below normal or absent reflexes)

What are the common drug interactions of Axid and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Platelet count decreased
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic dilatation
Aspartate aminotransferase increased
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood creatinine increased
Blood urea increased
Hydronephrosis (water inside the kidney)
Immunosuppressant drug level decreased

30-39:

Mouth ulceration (mouth ulcers)
Skin ulcer

40-49:

Abdominal pain
Fatigue (feeling of tiredness)
Graft loss (graft failure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Malaise (a feeling of general discomfort or uneasiness)
Oedema peripheral (superficial swelling)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Blood culture positive
Blood pressure increased
Fluid retention (an abnormal accumulation of fluid in the blood)

50-59:

Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Intervertebral disc degeneration (spinal disc degeneration)
Leukoencephalopathy (disease of the white matter in the brain)
Meningism (the triad of nuchal rigidity (neck stiffness), photophobia (intolerance of bright light) and headache. it is a sign of irritation of the meninges)
Mucosal erosion (peeling off of mucous membrane)
Neck pain
Nuchal rigidity (a resistance to flexion of the neck)
Oedema peripheral (superficial swelling)
Platelet count decreased
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)

60+:

Ataxia (loss of full control of bodily movements)
Gait abnormal
Blood creatinine increased
Blood magnesium increased
Blood urea increased
Constipation
Hypoaesthesia (reduced sense of touch or sensation)
Abdominal distension
Abdominal pain
Abdominal pain upper

What are the existing conditions these people have? *

Immunodeficiency Disorders: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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