Azactam and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azactam (aztreonam) and Senna (senna). Common drug interactions include chronic kidney disease among females and enterocolitis among males.

The phase IV clinical study analyzes what interactions people have when they take Azactam and Senna. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Azactam?

Azactam has active ingredients of aztreonam. eHealthMe is studying from 1,044 Azactam users. Check the latest studies of Azactam.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

15 people who take Azactam and Senna together, and have interactions are studied.

What are the common drug interactions of Azactam and Senna, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Death
Dyspnoea (difficult or laboured respiration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Ventricular extrasystoles (premature cardiac contraction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

male:

Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Hypoxia (low oxygen in tissues)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pneumothorax traumatic
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)

What are the common drug interactions of Azactam and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal failure (kidney dysfunction)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Ventricular extrasystoles (premature cardiac contraction)
Death

50-59:

Hypoxia (low oxygen in tissues)
Interstitial lung disease
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Haematocrit decreased
Haemoglobin decreased
Heart rate increased
Loss of consciousness
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Pneumonia

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Death
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Liver disorder (liver diseases)
Neutropenia (an abnormally low number of neutrophils)
Sepsis (a severe blood infection that can lead to organ failure and death)
Rash
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 46.67%
Pain: 6 people, 40.00%
Nausea (feeling of having an urge to vomit): 4 people, 26.67%
Infection: 4 people, 26.67%
Fever: 4 people, 26.67%
Joint Pain: 4 people, 26.67%
High Blood Cholesterol: 3 people, 20.00%
Swelling: 3 people, 20.00%
Herpes Simplex (herpes simplex is a common viral infection): 2 people, 13.33%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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