Azelastine and Mesalamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azelastine (azelastine hydrochloride) and Mesalamine (mesalamine). Common drug interactions include injection site pruritus among females and clostridium difficile colitis among males.

The phase IV clinical study analyzes what interactions people have when they take Azelastine and Mesalamine. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

On Aug, 06, 2026

72 people who take Azelastine and Mesalamine together, and have interactions are studied.

Azelastine and Mesalamine drug interactions.

What are the common drug interactions of Azelastine and Mesalamine, by gender? *:

female:

Injection site pruritus (severe itching at injection site)
Injection site rash
Injection site swelling
Injection site urticaria (rash of round, red welts on the skin at injection site)
Intervertebral disc protrusion (spinal disc protrusion)
Intestinal ulcer
Anxiety
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Respiratory distress (difficulty in breathing)

male:

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Pneumonia
Accidental exposure
Back pain
Blood disorder
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Dyspnoea (difficult or laboured respiration)
Ear infection

What are the common drug interactions of Azelastine and Mesalamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug hypersensitivity
Infusion related reaction
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Drug ineffective
Eosinophilic pneumonia (eosinophil accumulates in the lung)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Stent placement

20-29:

Abdominal pain upper
Administration site pain
Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Device related infection
Fatigue (feeling of tiredness)
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)
Post-traumatic stress disorder
Sleep disorder

30-39:

Anxiety
Heart rate decreased
Hypotension (abnormally low blood pressure)
Injection site bruising
Injection site pruritus (severe itching at injection site)
Injection site rash
Injection site urticaria (rash of round, red welts on the skin at injection site)
Palpitations (feelings or sensations that your heart is pounding or racing)
Precancerous skin lesion
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

40-49:

Pain
Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Back pain
Chronic kidney disease
Headache (pain in head)
Injection site pain
Intervertebral disc protrusion (spinal disc protrusion)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Drug ineffective
Septic shock (shock due to blood infection)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)

60+:

Influenza
Sedation
Dyspnoea (difficult or laboured respiration)
Gallbladder operation
Injection site haemorrhage (bleeding from injection site)
Pruritus (severe itching of the skin)
Scar
Skin irritation
Urinary tract infection
Anaemia (lack of blood)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 26.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 13.89%
High Blood Pressure: 8 people, 11.11%
Stress And Anxiety: 8 people, 11.11%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 9.72%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 6.94%
Multiple Allergies (allergy to multiple agents): 5 people, 6.94%
Pneumonia: 5 people, 6.94%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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