Azelastine and Rexulti drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azelastine (azelastine hydrochloride) and Rexulti (brexpiprazole). Common drug interactions include alopecia among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Azelastine and Rexulti. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

On Jul, 13, 2026

30 people who take Azelastine and Rexulti together, and have interactions are studied.

Azelastine and Rexulti drug interactions.

What are the common drug interactions of Azelastine and Rexulti, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Tinnitus (a ringing in the ears)
Asthma
Hospitalisation
Sinusitis (inflammation of sinus)
Suicidal ideation
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bipolar disorder (mood disorder)
Nephrolithiasis (calculi in the kidneys)

male:

Sinusitis (inflammation of sinus)
Nasopharyngitis (inflammation of the nasopharynx)
Lung disorder (lung disease)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Infection
Confusional state
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the common drug interactions of Azelastine and Rexulti, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthma
Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)
Injection site pain
Lethargy (tiredness)
Lung disorder (lung disease)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Sinusitis (inflammation of sinus)
Nasopharyngitis (inflammation of the nasopharynx)
Infection
Blood pressure increased
Dizziness
Drug ineffective
Fatigue (feeling of tiredness)
Hypersensitivity
Injection site discharge
Middle ear effusion (fluid in middle ear)

50-59:

Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Head discomfort
Hyperhidrosis (abnormally increased sweating)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Pyrexia (fever)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Agitation (state of anxiety or nervous excitement)
Crying
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

60+:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Nephrolithiasis (calculi in the kidneys)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 56.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 20.00%
Asthma: 6 people, 20.00%
Immunodeficiency: 4 people, 13.33%
Sleep Disorder: 2 people, 6.67%
Drowsiness: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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