Azelastine and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azelastine (azelastine hydrochloride) and Savella (milnacipran hydrochloride). Common drug interactions include asthma among females and myoclonic epilepsy among males.

The phase IV clinical study analyzes what interactions people have when they take Azelastine and Savella. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

45 people who take Azelastine and Savella together, and have interactions are studied.

Azelastine and Savella drug interactions.

What are the common drug interactions of Azelastine and Savella, by gender? *:

female:

Asthma
Blood potassium decreased
Blood pressure increased
Concussion (short loss of normal brain function in response to a head injury)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Pulmonary thrombosis (scarring in the lungs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)

male:

Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Neuropathy peripheral (surface nerve damage)
Cardiac disorder
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Azelastine and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal behaviour
Allergy to metals
Dizziness
Drug ineffective
Drug intolerance (drug sensitivity)
Herpes virus infection
Memory impairment
Nightmare (unpleasant dream)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Sinusitis (inflammation of sinus)

30-39:

n/a

40-49:

Spinal fusion surgery
Tooth infection
Asthma
Chronic kidney disease
Cough
Malaise (a feeling of general discomfort or uneasiness)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Rhinorrhoea (watery mucus discharge from the nose)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Gait disturbance
Sinusitis (inflammation of sinus)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Anxiety
Balance disorder
Blood creatinine increased
Blood pressure increased
Cardiac murmur (an heart sound in valve abnormality)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

60+:

Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Neuropathy peripheral (surface nerve damage)
Hypersensitivity
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Ulcer
Nausea (feeling of having an urge to vomit)
Concussion (short loss of normal brain function in response to a head injury)
Head injury

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 44.44%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 24.44%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.33%
Pain: 4 people, 8.89%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.89%
Insomnia (sleeplessness): 4 people, 8.89%
Stress And Anxiety: 3 people, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.67%
High Blood Cholesterol: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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