B12 and Cathflo activase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take B12 (cobalamin) and Cathflo activase (alteplase). Common drug interactions include fall among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take B12 and Cathflo activase. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.

What is Cathflo activase?

Cathflo activase has active ingredients of alteplase. eHealthMe is studying from 1,469 Cathflo activase users. Check the latest studies of Cathflo activase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

37 people who take B12 and Cathflo activase together, and have interactions are studied.

B12 and Cathflo activase drug interactions.

What are the common drug interactions of B12 and Cathflo Activase, by gender? *:

female:

Fall
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Vomiting
Blood pressure fluctuation
Infusion related reaction
Catheter site infection (infection at the site of insertion)
Chest discomfort
Chills (felling of cold)
Erythema (redness of the skin)

male:

Dizziness
Dehydration (dryness resulting from the removal of water)
Blood pressure decreased
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Hemiparesis (weakness on one side of the body)
Hemiplegia (paralysis of one side of the body)
Hypertension (high blood pressure)

What are the common drug interactions of B12 and Cathflo Activase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chest pain
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

n/a

30-39:

Blood pressure fluctuation
Fall
Headache (pain in head)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Vomiting
Catheter site infection (infection at the site of insertion)
Chest discomfort
Chills (felling of cold)
Erythema (redness of the skin)

40-49:

n/a

50-59:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Death
Oedema peripheral (superficial swelling)
Tenderness (pain or discomfort when an affected area is touched)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Weight increased

60+:

Dyspnoea (difficult or laboured respiration)
Dehydration (dryness resulting from the removal of water)
Dysphonia (speech disorder attributable to a disorder of phonation)
Gait disturbance
Hospitalisation
Ligament sprain (ligament stretched)
Lung disorder (lung disease)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Pneumonia

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 21.62%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 6 people, 16.22%
Pain: 6 people, 16.22%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 10.81%
Device Occlusion: 4 people, 10.81%
Nausea And Vomiting: 4 people, 10.81%
High Blood Pressure: 4 people, 10.81%
Hypokalemia (low potassium): 4 people, 10.81%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 3 people, 8.11%
Chest Pain: 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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