B12 and Twynsta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take B12 (cobalamin) and Twynsta (amlodipine besylate; telmisartan). Common drug interactions include nasopharyngitis among females and crohn's disease among males.

The phase IV clinical study analyzes what interactions people have when they take B12 and Twynsta. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.

What is Twynsta?

Twynsta has active ingredients of amlodipine besylate; telmisartan. It is often used in high blood pressure. eHealthMe is studying from 1,063 Twynsta users. Check the latest studies of Twynsta.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

29 people who take B12 and Twynsta together, and have interactions are studied.

What are the common drug interactions of B12 and Twynsta, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Pain
Wheezing (a high-pitched whistling sound made while you breath)
Malaise (a feeling of general discomfort or uneasiness)
Asthma
Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Respiratory tract infection
Weight decreased

male:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Neurological symptom (symptoms of nervous system disease)
Flushing (the warm, red condition of human skin)
Abdominal pain
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood potassium decreased

What are the common drug interactions of B12 and Twynsta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Pain
Wheezing (a high-pitched whistling sound made while you breath)
Malaise (a feeling of general discomfort or uneasiness)
Asthma
Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Respiratory tract infection
Weight decreased

50-59:

Abdominal pain
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Blood potassium decreased
Localised intraabdominal fluid collection (collection of fluid in abdomen in single site)
Nausea (feeling of having an urge to vomit)
Pain
Spleen disorder (disease of spleen)
Chest pain
Dyspnoea (difficult or laboured respiration)

60+:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Neurological symptom (symptoms of nervous system disease)
Flushing (the warm, red condition of human skin)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Contusion (a type of hematoma of tissue in which capillaries)
Small intestinal obstruction (blockage in small intestine)
Cerebral haemorrhage (bleeding within the brain)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 19 people, 65.52%
Asthma: 4 people, 13.79%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.90%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 6.90%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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