B12 and Vancomycin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take B12 (cobalamin) and Vancomycin hydrochloride (vancomycin hydrochloride). Common drug interactions include fistula among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take B12 and Vancomycin hydrochloride. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.

What is Vancomycin hydrochloride?

Vancomycin hydrochloride has active ingredients of vancomycin hydrochloride. It is often used in mrsa infection. eHealthMe is studying from 8,399 Vancomycin hydrochloride users. Check the latest studies of Vancomycin hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

84 people who take B12 and Vancomycin hydrochloride together, and have interactions are studied.

B12 and Vancomycin hydrochloride drug interactions.

What are the common drug interactions of B12 and Vancomycin Hydrochloride, by gender? *:

female:

Fistula (an abnormal connection or passageway between two)
Headache (pain in head)
Migraine (headache)
Back pain
Incontinence (lack of moderation or self-control)
Pneumonia
Productive cough
Sinusitis (inflammation of sinus)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Rash pruritic (redness with itching)

male:

Drug ineffective
Rash morbilliform (a rash that looks like measles)
Fibromyalgia (a long-term condition which causes pain all over the body)
Finger deformity (a deformed position of the finger)
Foot deformity (functional disability of foot)
Hepatic enzyme increased
Hypokinesia (decreased bodily movement)
Limb discomfort (discomfort in leg)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of B12 and Vancomycin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood creatinine increased
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

20-29:

Blood pressure increased
Galactorrhoea (secretion of breast milk in men)
Heart rate increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Suicidal ideation

30-39:

Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Skin burning sensation
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)

50-59:

Discomfort
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspepsia (indigestion)
Female genital tract fistula (passage in genital tract of female)
Fibromyalgia (a long-term condition which causes pain all over the body)
Fistula (an abnormal connection or passageway between two)
Flatulence (flatus expelled through the anus)
Food allergy
Frequent bowel movements
Haematocrit increased

60+:

Drug ineffective
Injection site mass
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Diarrhoea
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Urinary tract infection
Fistula (an abnormal connection or passageway between two)
Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Pain: 16 people, 19.05%
Respiratory Tract Infection: 11 people, 13.10%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 13.10%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 8 people, 9.52%
Bacteraemia (presence of bacteria in the blood): 8 people, 9.52%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 7.14%
Cellulitis (infection under the skin): 6 people, 7.14%
Staphylococcal Bacteraemia (a bacterial infection of blood): 5 people, 5.95%
Osteomyelitis (infection of bone): 5 people, 5.95%
High Blood Pressure: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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