Baclofen and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Baclofen (baclofen) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include somnolence among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Baclofen and Avalide. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,662 Baclofen users. Check the latest studies of Baclofen.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

On Jul, 31, 2026

40 people who take Baclofen and Avalide together, and have interactions are studied.

What are the common drug interactions of Baclofen and Avalide, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Renal failure (kidney dysfunction)
Aortic valve disease
Colon cancer stage iv
Depression
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)

male:

Fall
Insomnia (sleeplessness)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depression
Dysarthria (speech disorder)
Fatigue (feeling of tiredness)
Intervertebral disc degeneration (spinal disc degeneration)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain in extremity

What are the common drug interactions of Baclofen and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Bone disorder
Hyperhidrosis (abnormally increased sweating)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Rash
Upper respiratory tract infection
Vomiting
Abdominal pain
Abdominal pain upper

50-59:

Neoplasm malignant (cancer tumour)
Nephrolithiasis (calculi in the kidneys)
Neuritis (inflammation of nerve)
Nocardiosis (an infectious disease affecting either the lungs or whole body)
Nuclear magnetic resonance imaging brain
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Otitis media (inflammation of the middle ear)
Pain
Pain in extremity

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Alopecia (absence of hair from areas of the body)
Burning sensation
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chills (felling of cold)
Death
Dehydration (dryness resulting from the removal of water)
Malaise (a feeling of general discomfort or uneasiness)
Muscle cramp (painful sensation caused by muscle contraction)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 13 people, 32.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 25.00%
Pain: 5 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 10.00%
High Blood Cholesterol: 4 people, 10.00%
Gout (uric acid crystals building up in the body): 4 people, 10.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 10.00%
Fever: 3 people, 7.50%
Dizziness: 3 people, 7.50%
Irritable Bowel Syndrome: 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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