Baclofen and Gabitril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Baclofen (baclofen) and Gabitril (tiagabine hydrochloride). Common drug interactions include migraine among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Baclofen and Gabitril. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,662 Baclofen users. Check the latest studies of Baclofen.

What is Gabitril?

Gabitril has active ingredients of tiagabine hydrochloride. It is often used in epilepsy. eHealthMe is studying from 2,230 Gabitril users. Check the latest studies of Gabitril.

On Jul, 21, 2026

94 people who take Baclofen and Gabitril together, and have interactions are studied.

Baclofen and Gabitril drug interactions.

What are the common drug interactions of Baclofen and Gabitril, by gender? *:

female:

Migraine (headache)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Implant site swelling
Infection
Swelling
Cardiac ventricular thrombosis (blood clot in ventricle)
Drug hypersensitivity
Ejection fraction decreased (systolic heart failure)
Hyperhidrosis (abnormally increased sweating)

male:

Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Abdominal pain upper
Anxiety
Fall
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Neck pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the common drug interactions of Baclofen and Gabitril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Implant site swelling
Infection
Swelling
Abdominal pain
Coma (state of unconsciousness lasting more than six hours)
Drug toxicity
Lethargy (tiredness)
Vomiting
Back pain
Blood cholesterol increased

20-29:

Device failure
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

30-39:

Chest discomfort
Dyspnoea (difficult or laboured respiration)
Pain
Panic attack
Pneumonia
Sinusitis (inflammation of sinus)
Anxiety
Blood glucose increased
Decreased appetite
Difficulty in walking

40-49:

Pain
Cardiac ventricular thrombosis (blood clot in ventricle)
Chest pain
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Fall
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Weight increased
Cardiomyopathy (weakening of the heart muscle)

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Ventricular dysfunction (heart dysfunction)
Hangover
Heart rate increased
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Pain
Pneumonia
Suicide attempt
Swelling
Temporal arteritis (inflammation and damage to blood vessels that supply the head area)

60+:

Chest pain
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Comminuted fracture (bone has broken into several pieces)
Abdominal distension
Abnormal dreams
Constipation
Dyspnoea (difficult or laboured respiration)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 26 people, 27.66%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 18.09%
Pain: 16 people, 17.02%
Sleep Disorder: 13 people, 13.83%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 10.64%
Insomnia (sleeplessness): 7 people, 7.45%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 7.45%

* Approximation only. Some reports may have incomplete information.

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