Baclofen and Sinemet cr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Baclofen (baclofen) and Sinemet cr (carbidopa; levodopa). Common drug interactions include delusion among females and dyskinesia among males.

The phase IV clinical study analyzes what interactions people have when they take Baclofen and Sinemet cr. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,662 Baclofen users. Check the latest studies of Baclofen.

What is Sinemet cr?

Sinemet cr has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 2,852 Sinemet cr users. Check the latest studies of Sinemet cr.



On Jul, 05, 2026

42 people who take Baclofen and Sinemet cr together, and have interactions are studied.

Baclofen and Sinemet cr drug interactions.

What are the common drug interactions of Baclofen and Sinemet Cr, by gender? *:

female:

  1. Delusion (a false belief or opinion)
  2. Dementia (madness)
  3. Device dislocation
  4. Device expulsion
  5. Drug toxicity
  6. Dystonia (abnormal muscle tone)
  7. Emotional disorder
  8. Eructation (release of gas from the digestive tract)
  9. Erythema (redness of the skin)
  10. Escherichia test positive

male:

  1. Dyskinesia (abnormality or impairment of voluntary movement)
  2. On and off phenomenon
  3. General physical health deterioration (weak health status)
  4. Pneumonia
  5. Bipolar disorder (mood disorder)
  6. Gait disturbance
  7. Paradoxical drug reaction
  8. Speech disorder
  9. Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
  10. Diarrhoea

What are the common drug interactions of Baclofen and Sinemet Cr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Bipolar disorder (mood disorder)
  2. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Hyporeflexia (a condition of below normal or absent reflexes)
  5. Leg ulcer (exc varicose) (leg ulcer without varicose vein)
  6. Livedo reticularis (a lace-like purplish discoloration of the skin)
  7. Mania (a state of abnormally elevated or irritable mood)
  8. Muscle atrophy (a decrease in the mass of the muscle)
  9. Pain in limb
  10. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

  1. On and off phenomenon
  2. Abnormal faeces (abnormal stool)
  3. Constipation
  4. Depressed mood
  5. Depression
  6. Dysphagia (a condition in which swallowing is difficult or painful)
  7. Fall
  8. Feeding disorder (when children refuse to eat certain food groups)
  9. General physical health deterioration (weak health status)
  10. General symptom

60+:

  1. Dyskinesia (abnormality or impairment of voluntary movement)
  2. Muscle rigidity (muscle stiffness)
  3. Visual impairment
  4. Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
  5. Cardiac failure congestive
  6. Fatigue (feeling of tiredness)
  7. General physical health deterioration (weak health status)
  8. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  9. On and off phenomenon
  10. Paradoxical drug reaction

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 23.81%

* Approximation only. Some reports may have incomplete information.

Do you take Baclofen and Sinemet cr?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Baclofen and Sinemet cr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Baclofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Sinemet cr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Baclofen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sinemet cr and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on baclofen and carbidopa; levodopa (the active ingredients of Baclofen and Sinemet cr, respectively), and Baclofen and Sinemet cr (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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