Baclofen and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Baclofen (baclofen) and Wakix (pitolisant hydrochloride). Common drug interactions include muscular weakness among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Baclofen and Wakix. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,662 Baclofen users. Check the latest studies of Baclofen.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

On Jul, 10, 2026

65 people who take Baclofen and Wakix together, and have interactions are studied.

What are the common drug interactions of Baclofen and Wakix, by gender? *:

female:

Muscular weakness (muscle weakness)
Sleep talking (talking during sleeping)
Somnolence (a state of near-sleep, a strong desire for sleep)
Arthralgia (joint pain)
Back pain
Balance disorder
Cough
Decreased appetite
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

male:

Dizziness
Loss of consciousness
Fatigue (feeling of tiredness)
Somnambulism (sleep walking)
Fall
Blood iron increased
Cough
Dry mouth
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glaucoma (increased fluid pressure in the eye with vision loss)

What are the common drug interactions of Baclofen and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Affective disorder (mental disorder)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Coeliac disease (simple food intolerance)
Cold sweat
Depression
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypotension (abnormally low blood pressure)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Seasonal allergy (allergic condition due to certain season)

20-29:

Dyskinesia (abnormality or impairment of voluntary movement)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Injection site abscess
Inner ear disorder
Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
Muscle twitching
Mydriasis (a dilation of the pupil)
Panic attack
Post-traumatic stress disorder
Psychotic disorder

30-39:

Depression
Dry eye (lack of adequate tears)
Dry throat
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasal dryness (dry nose)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Pain of skin

40-49:

Abdominal discomfort
Abnormal dreams
Anxiety
Back pain
Blood potassium decreased
Body temperature increased
Catheter site pain
Chest pain
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)

50-59:

Feeling drunk
Headache (pain in head)
Muscular weakness (muscle weakness)
Sleep talking (talking during sleeping)
Vomiting
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Disturbance in attention
Drug intolerance (drug sensitivity)
Nephrolithiasis (calculi in the kidneys)

60+:

Initial insomnia (feeling of inadequate or poor-quality sleep)
Insomnia (sleeplessness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fall
Hospitalisation
Rib fracture
Surgery

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 60 people, 92.31%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 39 people, 60.00%
Drowsiness: 20 people, 30.77%

* Approximation only. Some reports may have incomplete information.

Do you take Baclofen and Wakix?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously