Bactrim and Aczone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Aczone (dapsone). Common drug interactions include dehydration among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Aczone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Aczone?

Aczone has active ingredients of dapsone. It is often used in acne. eHealthMe is studying from 1,152 Aczone users. Check the latest studies of Aczone.

On Jul, 27, 2026

20 people who take Bactrim and Aczone together, and have interactions are studied.

What are the common drug interactions of Bactrim and Aczone, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Abdominal distension
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depression
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hepatic steatosis (fatty liver disease)
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Postoperative wound infection

male:

Completed suicide (act of taking one's own life)
Drug ineffective
Anaemia (lack of blood)
Back pain
Dysphagia (a condition in which swallowing is difficult or painful)
Fungal infection
Neck pain
Oesophagitis ulcerative (inflammation of oesophagus with multiple ulcers)
Renal failure (kidney dysfunction)
Superinfection

What are the common drug interactions of Bactrim and Aczone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Completed suicide (act of taking one's own life)
Drug ineffective

20-29:

Anxiety
Abdominal pain upper
Adrenal disorder
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Coeliac disease (simple food intolerance)
Crying
Decreased appetite
Depression
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Mood altered (changes in mood)

30-39:

n/a

40-49:

Rash erythematous (redness of the skin)

50-59:

Abdominal distension
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Neck pain
Oesophagitis ulcerative (inflammation of oesophagus with multiple ulcers)
Renal failure (kidney dysfunction)
Superinfection
Hepatic steatosis (fatty liver disease)
Postoperative wound infection
Anaemia (lack of blood)
Back pain

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 65.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 40.00%
Drowsiness: 3 people, 15.00%
Pain: 1 person, 5.00%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 5.00%
Hypersensitivity: 1 person, 5.00%
Endocrine Ophthalmopathy (increased water content of retroocular orbital tissues; associated with thyroid disease, usually hyperthyroidism): 1 person, 5.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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