Bactrim and Evoxac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Evoxac (cevimeline hydrochloride). Common drug interactions include dysphonia among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Evoxac. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

On Jul, 11, 2026

48 people who take Bactrim and Evoxac together, and have interactions are studied.

What are the common drug interactions of Bactrim and Evoxac, by gender? *:

female:

Dysphonia (speech disorder attributable to a disorder of phonation)
Discomfort
Pain in jaw
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Feeling jittery
Fractured sacrum

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fluid retention (an abnormal accumulation of fluid in the blood)
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthropathy
Back pain
Body height decreased
Bone disorder
Bone loss
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Candidiasis (candidiasis or thrush is a fungal infection)

What are the common drug interactions of Bactrim and Evoxac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Scar
Acute sinusitis
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthropathy
Back pain
Bone disorder

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Gallbladder operation
Muscle spasms (muscle contraction)

40-49:

Alanine aminotransferase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Erythema (redness of the skin)
Fall
Fatigue (feeling of tiredness)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Injection site pain
Joint swelling

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cartilage atrophy (cartilage extra growth)
Discomfort
Fracture
Full blood count decreased
Hypotension (abnormally low blood pressure)
Influenza
Labyrinthitis (inflammation of the labyrinth or inner ear)
Loose tooth
Muscle spasms (muscle contraction)

60+:

Diarrhoea
Fall
Feeling jittery
Fractured sacrum
Gingival bleeding (bleeding gums)
Gingival disorder (gum disease)
Gingival hyperplasia (overgrowth of gums)
Gingival oedema (swelling of gums)
Gingivitis (inflammation of gums)
Heart rate increased

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 23 people, 47.92%
Multiple Myeloma (cancer of the plasma cells): 7 people, 14.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.42%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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