Bactrim and Ketalar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Ketalar (ketamine hydrochloride). Common drug interactions include pancreatitis among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Ketalar. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Ketalar?

Ketalar has active ingredients of ketamine hydrochloride. eHealthMe is studying from 1,226 Ketalar users. Check the latest studies of Ketalar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

20 people who take Bactrim and Ketalar together, and have interactions are studied.

What are the common drug interactions of Bactrim and Ketalar, by gender? *:

female:

Pancreatitis (inflammation of pancreas)
Blood creatine phosphokinase increased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Leukoencephalopathy (disease of the white matter in the brain)
Anaemia (lack of blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Hypoxia (low oxygen in tissues)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

male:

Hypertension (high blood pressure)
Haematuria (presence of blood in urine)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)

What are the common drug interactions of Bactrim and Ketalar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypertension (high blood pressure)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Pancreatitis (inflammation of pancreas)
White blood cell count increased

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

Hypovolaemic shock (shock caused by severe blood or fluid loss)
Overdose
Renal failure (kidney dysfunction)
Renal tubular disorder (disease of kidney tubules)
Septic shock (shock due to blood infection)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

30-39:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Leukoencephalopathy (disease of the white matter in the brain)
Pancreatitis (inflammation of pancreas)

40-49:

Blood creatine phosphokinase increased
Anaemia (lack of blood)
Haematuria (presence of blood in urine)
Hypoxia (low oxygen in tissues)
Platelet count decreased
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
Malignant neoplasm progression (cancer tumour came back)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)
Venoocclusive liver disease (small veins in the liver are obstructed)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Fungal sepsis (whole body infection by fungus)

60+:

Dilatation intrahepatic duct acquired
Hepatotoxicity (chemical-driven liver damage)
Venoocclusive liver disease (small veins in the liver are obstructed)
Alanine aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)

What are the existing conditions these people have? *

Pain: 3 people, 15.00%
Respiratory Tract Oedema (swelling of respiratory tract due to excess fluid collection in tissue): 3 people, 15.00%
Hypotension (abnormally low blood pressure): 3 people, 15.00%
Infection: 3 people, 15.00%
Asthma: 3 people, 15.00%
Sedation: 2 people, 10.00%
Essential Hypertension (primary hypertension): 2 people, 10.00%
Hyperglycemia (high blood sugar): 2 people, 10.00%
Immunodeficiency Disorders: 2 people, 10.00%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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