Bactrim and Malarone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Malarone (atovaquone; proguanil hydrochloride). Common drug interactions include vanishing bile duct syndrome among females and abasia among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Malarone. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Malarone?

Malarone has active ingredients of atovaquone; proguanil hydrochloride. It is often used in malaria. eHealthMe is studying from 3,098 Malarone users. Check the latest studies of Malarone.

On Jul, 11, 2026

14 people who take Bactrim and Malarone together, and have interactions are studied.

What are the common drug interactions of Bactrim and Malarone, by gender? *:

female:

Vanishing bile duct syndrome (loose collection of diseases which leads to the injury to hepatic bile ducts and eventual ductopenia)
Cholestatic liver injury (due to injury bile cannot floe from liver)
Drug ineffective
Hepatocellular injury (liver injury)
Rash morbilliform (a rash that looks like measles)

male:

Abasia (inability to walk)
Abdominal distension
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Stomatitis (inflammation of mucous membrane of mouth)
Swollen tongue (swelling of tongue)
Tongue ulceration (ulcers on tongue)
Upper respiratory tract infection
Adverse drug reaction
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea

What are the common drug interactions of Bactrim and Malarone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hepatocellular injury (liver injury)
Rash morbilliform (a rash that looks like measles)

40-49:

Abasia (inability to walk)
Adverse drug reaction
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Mouth ulceration (mouth ulcers)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Tongue ulceration (ulcers on tongue)
Upper respiratory tract infection

50-59:

n/a

60+:

Vanishing bile duct syndrome (loose collection of diseases which leads to the injury to hepatic bile ducts and eventual ductopenia)
Cholestatic liver injury (due to injury bile cannot floe from liver)
Swollen tongue (swelling of tongue)
Drug ineffective
Abdominal distension
Diarrhoea
Flatulence (flatus expelled through the anus)
Gastric ulcer (stomach ulcer)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)

What are the existing conditions these people have? *

Lyme Disease (a bacterial infection that is spread to humans by infected ticks): 1 person, 7.14%
Babesiosis (malaria-like parasitic disease caused by infection with babesia): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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