Bactrim and Marcaine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Marcaine (bupivacaine hydrochloride). Common drug interactions include deep vein thrombosis among females and hypoxia among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Marcaine. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Marcaine?

Marcaine has active ingredients of bupivacaine hydrochloride. It is often used in pain. eHealthMe is studying from 4,026 Marcaine users. Check the latest studies of Marcaine.

On Aug, 05, 2026

31 people who take Bactrim and Marcaine together, and have interactions are studied.

What are the common drug interactions of Bactrim and Marcaine, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Deformity (disfigurement)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Speech disorder
Vomiting
Actinomyces test positive
Acute psychosis (period of mentally unstable behaviour)

male:

Hypoxia (low oxygen in tissues)
Pyrexia (fever)
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatomegaly (abnormal enlargement of the liver)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Bactrim and Marcaine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)

20-29:

Actinomyces test positive
Acute psychosis (period of mentally unstable behaviour)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Bone disorder
Breath odour
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Candidiasis (candidiasis or thrush is a fungal infection)
Cellulitis (infection under the skin)
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)

30-39:

Abdominal pain
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Thrombosis (formation of a blood clot inside a blood vessel)

40-49:

Epistaxis (bleed from the nose)
Exostosis (formation of new bone on the surface of a bone)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Rash
Abscess (pus)
Back pain
Blood creatinine increased
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
International normalised ratio increased

50-59:

Anxiety
Asthma
Back pain
Bacteriuria (presence of bacteria in urine)
Blood alkaline phosphatase increased
Blood cholesterol increased
Blood triglycerides increased
Blood urea increased
Blood urine present
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)

60+:

Fatigue (feeling of tiredness)
Pneumonia
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hypokalaemia (low potassium)
Hypoxia (low oxygen in tissues)
Mitral valve incompetence (inefficient heart valve)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Fever: 9 people, 29.03%
Respiratory Tract Infection: 8 people, 25.81%
Renal Cell Carcinoma (a kidney cancer): 8 people, 25.81%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 25.81%
Psychotic Disorder: 8 people, 25.81%
Pneumonia: 8 people, 25.81%
Dyspnea (difficult or laboured breathing): 8 people, 25.81%
Oedema (fluid collection in tissue): 8 people, 25.81%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 16.13%
Stress And Anxiety: 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

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