Bactrim and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Naltrexone (naltrexone). Common drug interactions include viral infection among females and subileus among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Naltrexone. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,835 Naltrexone users. Check the latest studies of Naltrexone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

83 people who take Bactrim and Naltrexone together, and have interactions are studied.

Bactrim and Naltrexone drug interactions.

What are the common drug interactions of Bactrim and Naltrexone, by gender? *:

female:

Viral infection
Weight decreased
White blood cell count decreased
Abdominal distension
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood magnesium decreased
Bronchial disorder
Cough

male:

Subileus
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Bone density decreased
Death
Depression
Emotional distress
Fungal infection
Insomnia (sleeplessness)
Osteonecrosis (death of bone)
Productive cough

What are the common drug interactions of Bactrim and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Bartonellosis (infectious disease produced by bacteria of the genus bartonella)
Dark circles under eyes
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Mycotic allergy (fungal allergy)
Vomiting
Fungal infection
Viral infection

10-19:

Headache (pain in head)
Insomnia (sleeplessness)
Migraine (headache)

20-29:

Nausea (feeling of having an urge to vomit)
Decreased appetite
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

30-39:

Overdose
Drug ineffective
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Anxiety
Bone density decreased
Death
Depression
Drug dependence
Emotional distress
Nausea (feeling of having an urge to vomit)

40-49:

Subileus

50-59:

Asthenia (weakness)
Depression
Dizziness
Drug hypersensitivity
Dysstasia (difficulty in standing)
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Insomnia (sleeplessness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

60+:

Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Death
Drug hypersensitivity
Haemorrhage (bleeding)
Hunger
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Weight decreased
Weight increased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 20 people, 24.10%
Otitis (ear infection): 11 people, 13.25%
Childhood Psychosis (abnormal condition of the mind of child, loss of contact with reality): 11 people, 13.25%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 9 people, 10.84%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 9.64%
Sleep Disorder: 7 people, 8.43%
Primary Immunodeficiency Syndrome: 5 people, 6.02%
Insomnia (sleeplessness): 5 people, 6.02%
Hiv Infection: 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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