Bactrim and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Nucynta (tapentadol hydrochloride). Common drug interactions include fear among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Nucynta. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 05, 2026

50 people who take Bactrim and Nucynta together, and have interactions are studied.

What are the common drug interactions of Bactrim and Nucynta, by gender? *:

female:

Fear
Fractured sacrum
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Hallucination (an experience involving the perception of something not present)
Hyperaesthesia
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Death
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Fall
Fatigue (feeling of tiredness)

What are the common drug interactions of Bactrim and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Drug diversion
Psychotic disorder
Suicidal ideation

30-39:

Poor venous access

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
Fear
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Quality of life decreased

50-59:

Chronic kidney disease
Blood pressure increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Escherichia infection (bacterial infection by escherichia coli)
Fatigue (feeling of tiredness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neoplasm malignant (cancer tumour)

60+:

Drug hypersensitivity
Angina pectoris (chest pain due to ischemia of the heart muscle)
Fall
Herpes zoster
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Immune system disorder
Influenza like illness
Local swelling (swelling at the site of some application of substance or injury)
Loss of consciousness
Neck pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 20.00%
High Blood Pressure: 9 people, 18.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 16.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 12.00%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 5 people, 10.00%
Multiple Myeloma (cancer of the plasma cells): 4 people, 8.00%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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