Bactrim and Onfi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Onfi (clobazam). Common drug interactions include radiculopathy among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Onfi. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Onfi?

Onfi has active ingredients of clobazam. It is often used in epilepsy. eHealthMe is studying from 7,809 Onfi users. Check the latest studies of Onfi.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

26 people who take Bactrim and Onfi together, and have interactions are studied.

What are the common drug interactions of Bactrim and Onfi, by gender? *:

female:

Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Rash erythematous (redness of the skin)
Red man syndrome (a reaction to the drug vancomycin)
Skin discolouration (change of skin colour)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Staphylococcal infection (an infection with staphylococcus bacteria)
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Subcutaneous abscess
Tracheitis (an inflammation of the trachea)
Transferrin decreased

male:

Anxiety
Dizziness
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardiac arrest
Concussion (short loss of normal brain function in response to a head injury)
Decreased appetite
Drug level increased
Encephalitis (inflammation of the brain)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Fall

What are the common drug interactions of Bactrim and Onfi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Vomiting
Altered state of consciousness (altered state of mind)
Body temperature increased
Cerebral disorder (brain disease)
Concussion (short loss of normal brain function in response to a head injury)
Drug level increased
Fall
Lethargy (tiredness)
Peripheral swelling
Urinary retention (the inability to completely or partially empty the bladder)

10-19:

Pneumonia
Hospitalisation

20-29:

n/a

30-39:

Apnoea (suspension of external breathing)
Bacterial infection
Bronchial obstruction (blockage of the breathing passages to the lungs)
Cardiac arrest
Cellulitis (infection under the skin)
Coeliac disease (simple food intolerance)
Decreased appetite
Foot fracture
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)

40-49:

Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Fungal oesophagitis (fungal inflammation of the oesophagus)
Joint injury
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Weight decreased
Wound infection

50-59:

Pulmonary tuberculosis (lungs tuberculosis)
Skin lesion
Thrombocytopenia (decrease of platelets in blood)
Transaminases increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Encephalitis (inflammation of the brain)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Generalised erythema (redness of the skin all over the body)
Hepatitis acute
Liver injury

60+:

Blood pressure decreased
Bradycardia (abnormally slow heart action)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 4 people, 15.38%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 11.54%
Primary Immunodeficiency Syndrome: 3 people, 11.54%
Swelling: 2 people, 7.69%
Pneumocystis Test Positive: 2 people, 7.69%
Neuralgia (pain in one or more nerves): 2 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%
Chronic Granulomatous Disease (immune system cells are unable to kill some types of bacteria and fungi): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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