Bactrim and Silenor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Silenor (doxepin hydrochloride). Common drug interactions include drug intolerance among females.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Silenor. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Silenor?

Silenor has active ingredients of doxepin hydrochloride. It is often used in insomnia. eHealthMe is studying from 635 Silenor users. Check the latest studies of Silenor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

14 people who take Bactrim and Silenor together, and have interactions are studied.

What are the common drug interactions of Bactrim and Silenor, by gender? *:

female:

Drug intolerance (drug sensitivity)
Fungal infection
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pruritus (severe itching of the skin)
Rash
Scar
Urine abnormality
White blood cells urine positive
Impaired gastric emptying

male:

n/a

What are the common drug interactions of Bactrim and Silenor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Urine abnormality
White blood cells urine positive
Blood urine present
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

60+:

Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Diarrhoea
Abdominal discomfort
Ovarian cancer (cancer of ovary)
Pruritus (severe itching of the skin)
Rash
Scar

What are the existing conditions these people have? *

Sleep Disorder: 9 people, 64.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
Drowsiness: 3 people, 21.43%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 14.29%
Nausea (feeling of having an urge to vomit): 2 people, 14.29%
Headache (pain in head): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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