Bactrim and Suprax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Suprax (cefixime). Common drug interactions include ectopic pregnancy among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Suprax. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Suprax?

Suprax has active ingredients of cefixime. eHealthMe is studying from 965 Suprax users. Check the latest studies of Suprax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

26 people who take Bactrim and Suprax together, and have interactions are studied.

What are the common drug interactions of Bactrim and Suprax, by gender? *:

female:

Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Emotional distress
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Erythema (redness of the skin)
Eyelid ptosis (falling of the upper or lower eyelid)
Fat tissue increased
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gastritis (inflammation of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Growth retardation (delayed growth)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Antisocial behaviour
Asthma
Blood creatinine increased
Blood urine present
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest tightness
Cough

What are the common drug interactions of Bactrim and Suprax, by age (0-1 to 60+)? *:

0-1:

Clostridium test positive
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Pyrexia (fever)
Viral infection
Vomiting

2-9:

Arthralgia (joint pain)
Oedema lower limb (fluid collection in tissue of lower leg)
Osteoporosis (bones weak and more likely to break)
Thrombophlebitis deep (deep swelling (inflammation) of a vein caused by a blood clot)

10-19:

Abdominal mass (localized enlargement or swelling in the human abdomen)
Acute respiratory failure
Asthenia (weakness)
Back pain
Body height decreased
Breath sounds
Clubbing (deformity of the fingers and fingernails)
Diarrhoea
Eyelid ptosis (falling of the upper or lower eyelid)
Fat tissue increased

20-29:

Cough
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Intestinal obstruction
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Ovarian cyst (fluid filled sac of the ovary)
Pelvic pain

30-39:

Asthma
Blood creatinine increased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest tightness
Dehydration (dryness resulting from the removal of water)
Drug effect decreased
Dyspnoea (difficult or laboured respiration)
Gastro-oesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Loin pain (pain originates from kidney)

40-49:

Pain in extremity
Pericardial effusion (fluid around the heart)
Pericarditis (inflammation of the pericardium)
Pericarditis rheumatic (active rheumatic heart disease)
Pleural effusion (water on the lungs)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Productive cough
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pyrexia (fever)

50-59:

Neuropathy peripheral (surface nerve damage)
Otitis externa (external ear infection)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Pyrexia (fever)
Restless legs syndrome (a powerful urge to move your legs)
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Tendonitis (a condition that causes pain and swelling of tendons)
Type 2 diabetes mellitus
Vaginal infection
Otitis media (inflammation of the middle ear)

60+:

Back pain
Hypersensitivity
Immune system disorder

What are the existing conditions these people have? *

Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 15.38%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 15.38%
Hiv Infection: 2 people, 7.69%
Cystic Fibrosis (disease of the secretary glands): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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