Bactrim and Tapazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Tapazole (methimazole). Common drug interactions include dysgeusia among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Tapazole. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Tapazole?

Tapazole has active ingredients of methimazole. It is often used in hyperthyroidism. eHealthMe is studying from 2,477 Tapazole users. Check the latest studies of Tapazole.

On Jul, 23, 2026

19 people who take Bactrim and Tapazole together, and have interactions are studied.

What are the common drug interactions of Bactrim and Tapazole, by gender? *:

female:

Dysgeusia (disorder of the sense of taste)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulse absent
Pyrexia (fever)
Rheumatoid vasculitis (inflammation of veins with painful joints and morning stiffness)
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight decreased

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Death
Facial bones fracture (bone fracture of face)
Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Bactrim and Tapazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Nephrogenic fibrosing dermopathy (involves fibrosis of skin, joints, eyes due to kidney disease)

40-49:

Drug hypersensitivity
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

n/a

60+:

Cough
Dyspnoea (difficult or laboured respiration)
Pulse absent
Rheumatoid vasculitis (inflammation of veins with painful joints and morning stiffness)
Weight decreased
Angiopathy (generic term for a disease of the blood vessels)
Arrhythmia (irregular heartbeat)
Arterial embolism limb
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 3 people, 15.79%
Multiple Myeloma (cancer of the plasma cells): 3 people, 15.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 10.53%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 2 people, 10.53%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 10.53%
Weight Decreased: 1 person, 5.26%
Type 2 Diabetes: 1 person, 5.26%
Stress And Anxiety: 1 person, 5.26%
Skin Discoloration: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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