Bactrim and Tikosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Tikosyn (dofetilide). Common drug interactions include ventricular tachycardia among females and hepatitis acute among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Tikosyn. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

31 people who take Bactrim and Tikosyn together, and have interactions are studied.

What are the common drug interactions of Bactrim and Tikosyn, by gender? *:

female:

Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Anger
Cardiac arrest
Cardiac disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)

male:

Hepatitis acute
Asthenia (weakness)
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blepharitis (chronic inflammation of the eyelid)

What are the common drug interactions of Bactrim and Tikosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac arrest
Cellulitis (infection under the skin)
Chest discomfort
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Influenza
Malaise (a feeling of general discomfort or uneasiness)

40-49:

Headache (pain in head)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pyrexia (fever)

50-59:

Asthenia (weakness)
Electrocardiogram qt prolonged
Ventricular extrasystoles (premature cardiac contraction)

60+:

Hepatitis acute
Fall
Atelectasis (partial or complete collapse of the lung)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blepharitis (chronic inflammation of the eyelid)
Blood pressure decreased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 3 people, 9.68%
Stress And Anxiety: 2 people, 6.45%
Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 2 people, 6.45%
Malignant Melanoma (skin cancer rises from melancytes): 2 people, 6.45%
Itching: 2 people, 6.45%
High Blood Pressure: 2 people, 6.45%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 6.45%
Breast Cancer Female: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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