Benlysta and Otezla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benlysta (belimumab) and Otezla (apremilast). Common drug interactions include fatigue among females and adverse reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Benlysta and Otezla. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Benlysta?

Benlysta has active ingredients of belimumab. It is often used in systemic lupus erythematosus. eHealthMe is studying from 23,528 Benlysta users. Check the latest studies of Benlysta.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

On Aug, 08, 2026

14 people who take Benlysta and Otezla together, and have interactions are studied.

What are the common drug interactions of Benlysta and Otezla, by gender? *:

female:

Fatigue (feeling of tiredness)
Joint swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Rash
Gait disturbance
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Arthropathy
Blood glucose increased

male:

Adverse reaction
Diarrhoea
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Benlysta and Otezla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pericarditis (inflammation of the pericardium)
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Pain

50-59:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Arthralgia (joint pain)
Arthropathy
Blood glucose increased
Blood pressure increased
Drug hypersensitivity
Drug ineffective
Drug intolerance (drug sensitivity)
Fatigue (feeling of tiredness)
Femur fracture

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Ill-defined disorder
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Skin disorder (skin disease)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 35.71%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 21.43%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 14.29%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 7.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 7.14%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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