Bentyl and Bisacodyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bentyl (dicyclomine hydrochloride) and Bisacodyl (bisacodyl). Common drug interactions include pneumonia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Bentyl and Bisacodyl. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Bentyl?

Bentyl has active ingredients of dicyclomine hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 10,754 Bentyl users. Check the latest studies of Bentyl.

What is Bisacodyl?

Bisacodyl has active ingredients of bisacodyl. It is often used in constipation. eHealthMe is studying from 18,852 Bisacodyl users. Check the latest studies of Bisacodyl.

On Aug, 11, 2026

41 people who take Bentyl and Bisacodyl together, and have interactions are studied.

What are the common drug interactions of Bentyl and Bisacodyl, by gender? *:

female:

Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Premature labour
Rectal haemorrhage (bleeding from anus)
Renal tubular necrosis (death of kidney tubules)
Therapeutic response decreased (less preventive response)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Wrist fracture
Pain

male:

Renal failure (kidney dysfunction)
Diarrhoea
Fungaemia (fungi circulate in the blood)
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))
Hypersensitivity
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Multi-organ failure (multisystem organ failure)
Necrosis (the death of body tissue)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Bentyl and Bisacodyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Chordee (a condition in which the head of the penis curves downward or upward, at the junction of the head)
Deformity (disfigurement)
Developmental delay
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Emotional distress
Encephalopathy (functioning of the brain is affected by some agent or condition)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Muscular weakness (muscle weakness)
Otitis media acute (rapid inflammation of the middle ear)

10-19:

Device related infection
Dyspnoea (difficult or laboured respiration)
Increased upper airway secretion
Moraxella infection (bacterial infection)
Staphylococcal infection (an infection with staphylococcus bacteria)

20-29:

Emotional disorder
Premature labour

30-39:

Acute hepatic failure
Fungal infection
Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Staphylococcal infection (an infection with staphylococcus bacteria)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bone density decreased
Emotional distress
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pain
Bone loss
Osteonecrosis (death of bone)

50-59:

Chronic kidney disease
Decreased appetite
Depression
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Heart rate increased
Hypoaesthesia (reduced sense of touch or sensation)
Hypoglycaemia (deficiency of glucose in the bloodstream)

60+:

Respiratory failure (inadequate gas exchange by the respiratory system)
Renal failure (kidney dysfunction)
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))
Hypersensitivity
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Multi-organ failure (multisystem organ failure)
Necrosis (the death of body tissue)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Pain: 13 people, 31.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 21.95%
High Blood Pressure: 8 people, 19.51%
High Blood Cholesterol: 7 people, 17.07%
Nausea (feeling of having an urge to vomit): 6 people, 14.63%
Diabetes: 5 people, 12.20%
Hiv Infection: 4 people, 9.76%
Gastrointestinal Stromal Tumor: 4 people, 9.76%
Stress And Anxiety: 3 people, 7.32%
Otitis (ear infection): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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