Bentyl and Dulcolax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bentyl (dicyclomine hydrochloride) and Dulcolax (bisacodyl). Common drug interactions include cardiac failure congestive among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Bentyl and Dulcolax. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Bentyl?

Bentyl has active ingredients of dicyclomine hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 10,754 Bentyl users. Check the latest studies of Bentyl.

What is Dulcolax?

Dulcolax has active ingredients of bisacodyl. It is often used in constipation. eHealthMe is studying from 12,897 Dulcolax users. Check the latest studies of Dulcolax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

57 people who take Bentyl and Dulcolax together, and have interactions are studied.

What are the common drug interactions of Bentyl and Dulcolax, by gender? *:

female:

Cardiac failure congestive
Confusional state
Depression
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Drug ineffective
Flatulence (flatus expelled through the anus)
Pain in extremity
Premature labour
Weight decreased

male:

Asthenia (weakness)
Diarrhoea
Fall
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate decreased
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)

What are the common drug interactions of Bentyl and Dulcolax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Chordee (a condition in which the head of the penis curves downward or upward, at the junction of the head)
Deformity (disfigurement)
Developmental delay
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Emotional distress
Encephalopathy (functioning of the brain is affected by some agent or condition)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Muscular weakness (muscle weakness)
Otitis media acute (rapid inflammation of the middle ear)

10-19:

Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Iron deficiency anaemia
Nephrolithiasis (calculi in the kidneys)
Neuropathy peripheral (surface nerve damage)
Pain
Pancreatitis (inflammation of pancreas)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Syncope (loss of consciousness with an inability to maintain postural tone)

20-29:

Emotional disorder
Premature labour

30-39:

Abdominal distension
Fluid overload (too much fluid in the blood)
Renal pain (kidney pain)

40-49:

Weight increased
Fibromyalgia (a long-term condition which causes pain all over the body)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Urinary tract infection
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma

50-59:

Hypertensive heart disease
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Intervertebral disc degeneration (spinal disc degeneration)
Iron deficiency
Large intestine perforation (hole in large intestine)
Left ventricular failure (left ventricle fails to contract forcefully)
Ligament sprain (ligament stretched)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Muscle spasms (muscle contraction)

60+:

Asthenia (weakness)
Weight decreased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Failure to thrive (inadequate weight gain and physical growth in children)
Fall
Flatulence (flatus expelled through the anus)
Heart rate decreased
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

What are the existing conditions these people have? *

Pain: 10 people, 17.54%
Nausea (feeling of having an urge to vomit): 10 people, 17.54%
Depression: 9 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 14.04%
Multiple Myeloma (cancer of the plasma cells): 6 people, 10.53%
Stress And Anxiety: 6 people, 10.53%
Nausea And Vomiting: 5 people, 8.77%
High Blood Cholesterol: 5 people, 8.77%
Birth Control: 4 people, 7.02%
Parkinson's Disease: 4 people, 7.02%

* Approximation only. Some reports may have incomplete information.

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