Benzonatate and Buspar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Buspar (buspirone hydrochloride). Common drug interactions include schizoaffective disorder among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Buspar. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,464 Buspar users. Check the latest studies of Buspar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

65 people who take Benzonatate and Buspar together, and have interactions are studied.

Benzonatate and Buspar drug interactions.

What are the common drug interactions of Benzonatate and Buspar, by gender? *:

female:

Schizoaffective disorder (a mental disorder characterized by disordered thought)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tendonitis (a condition that causes pain and swelling of tendons)
Vaginal infection
Adnexa uteri mass (ovarian cysts)
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Otitis media (inflammation of the middle ear)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Aphasia (damage to the parts of the brain that control language)
Bone pain
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coma (state of unconsciousness lasting more than six hours)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness

What are the common drug interactions of Benzonatate and Buspar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hodgkin's disease (cancer originating from white blood cells)
Impetigo (contagious skin infection)
Keratoconjunctivitis sicca (inflammation of the conjunctiva and cornea of the eye with decreased tears)
Lacrimation increased
Lung disorder (lung disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neuropathy peripheral (surface nerve damage)
Oral herpes (viral infection of mouth)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)

30-39:

Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Premature delivery
Administration related reaction
Angioedema (rapid swelling of the dermis)
Chronic kidney disease
Hypoxia (low oxygen in tissues)
Oxygen saturation decreased
Renal failure (kidney dysfunction)

40-49:

Hepatomegaly (abnormal enlargement of the liver)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Suicidal ideation
Vomiting
Weight decreased
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Abdominal discomfort
Accidental death

50-59:

Post procedural infection
Psoas abscess (collection of pus in the iliopsoas muscle compartment)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sensory disturbance (sense disturbance)
Speech disorder
Synovial cyst (cyst of joint filled with synovial fluid)
Tobacco user
Varicose vein (veins that have become enlarged and tortuous)
Vertigo
Vitamin b12 deficiency

60+:

Chronic kidney disease
Glomerulonephritis minimal lesion (a disease of the kidney that causes nephrotic syndrome and usually affects children)
Balance disorder
Blood cholesterol increased
Blood creatine phosphokinase increased
Blood creatinine increased
Blood triglycerides increased
Blood urea increased
Electrocardiogram qt prolonged
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 24.62%
Nausea (feeling of having an urge to vomit): 13 people, 20.00%
Depression: 12 people, 18.46%
Pain: 11 people, 16.92%
High Blood Pressure: 11 people, 16.92%
High Blood Cholesterol: 9 people, 13.85%
Infection: 8 people, 12.31%
Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 12.31%
Muscle Spasms (muscle contraction): 7 people, 10.77%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 7 people, 10.77%

* Approximation only. Some reports may have incomplete information.

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