Benzonatate and Estropipate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Estropipate (estropipate). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Estropipate. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Estropipate?

Estropipate has active ingredients of estropipate. It is often used in hormone replacement therapy. eHealthMe is studying from 1,659 Estropipate users. Check the latest studies of Estropipate.

On Jul, 25, 2026

12 people who take Benzonatate and Estropipate together, and have interactions are studied.

Benzonatate and Estropipate drug interactions.

What are the common drug interactions of Benzonatate and Estropipate, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Procedural pain
Tooth fracture
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Blood urine present
Bone fragmentation
Diarrhoea
Gingival bleeding (bleeding gums)
Gingivitis (inflammation of gums)

male:

n/a

What are the common drug interactions of Benzonatate and Estropipate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Chest pain
Colonic polyp (extra part of colon tissue grow in intestine)
Diarrhoea
Dyspepsia (indigestion)
Eructation (release of gas from the digestive tract)
Faecal incontinence (a lack of control over passing stool)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Irritable bowel syndrome
Lipoma (a growth of fatty tissue that slowly develops just under your skin)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood urine present
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain
Alopecia (absence of hair from areas of the body)
Blood cortisol decreased
Drug ineffective
Epistaxis (bleed from the nose)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Bone fragmentation
Gingival bleeding (bleeding gums)
Gingivitis (inflammation of gums)
Impaired healing
Jaw disorder (jaw disease)
Mouth ulceration (mouth ulcers)
Tooth infection

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 41.67%
Pain: 4 people, 33.33%
Hypersensitivity: 4 people, 33.33%
Diabetes: 4 people, 33.33%
Depression: 4 people, 33.33%
High Blood Pressure: 3 people, 25.00%
Gastric Ph Decreased: 3 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Oedema (fluid collection in tissue): 1 person, 8.33%
Infection: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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