Benzonatate and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Keytruda (pembrolizumab). Common drug interactions include vomiting among females and pain in extremity among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Keytruda. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

On Jul, 12, 2026

47 people who take Benzonatate and Keytruda together, and have interactions are studied.

Benzonatate and Keytruda drug interactions.

What are the common drug interactions of Benzonatate and Keytruda, by gender? *:

female:

Vomiting
Constipation
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Neuropathy peripheral (surface nerve damage)
Pneumonia
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Arthralgia (joint pain)

male:

Pain in extremity
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Blood calcium decreased
Blood pressure increased
Chest pain
Constipation
Dry skin
Hepatic enzyme decreased
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Benzonatate and Keytruda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mucosal inflammation (infection of mucous membrane)
Rash papular (redness with papule)
Upper respiratory tract infection

40-49:

Death

50-59:

Diarrhoea
Asthenia (weakness)
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dysphagia (a condition in which swallowing is difficult or painful)
Headache (pain in head)
Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)

60+:

Pain in extremity
Stomatitis (inflammation of mucous membrane of mouth)
Nausea (feeling of having an urge to vomit)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
White blood cell count decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Arthralgia (joint pain)
Blood calcium decreased
Blood pressure increased
Chest pain

What are the existing conditions these people have? *

Endometrial Cancer: 7 people, 14.89%
Lung Neoplasm Malignant (cancer tumour of lung): 5 people, 10.64%
Renal Cancer Metastatic (cancer of kidney spreads to other part): 4 people, 8.51%
Carcinoid Tumor Of The Duodenum: 3 people, 6.38%
Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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