Benzonatate and Macrodantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Macrodantin (nitrofurantoin, macrocrystalline). Common drug interactions include headache among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Macrodantin. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

On Jul, 26, 2026

39 people who take Benzonatate and Macrodantin together, and have interactions are studied.

Benzonatate and Macrodantin drug interactions.

What are the common drug interactions of Benzonatate and Macrodantin, by gender? *:

female:

Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stomatitis (inflammation of mucous membrane of mouth)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthma
Ataxia (loss of full control of bodily movements)

male:

Acute respiratory failure
Coma (state of unconsciousness lasting more than six hours)
Urinary tract obstruction
Diarrhoea
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dysphagia (a condition in which swallowing is difficult or painful)
Hemiplegia (paralysis of one side of the body)
Leukocytosis (increased white blood cells)

What are the common drug interactions of Benzonatate and Macrodantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Feeling hot
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Nausea (feeling of having an urge to vomit)
Retching (strong involuntary effort to vomit)
Vomiting

50-59:

Acute respiratory failure
Coma (state of unconsciousness lasting more than six hours)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dysphagia (a condition in which swallowing is difficult or painful)
Hemiplegia (paralysis of one side of the body)
Leukocytosis (increased white blood cells)
Pneumonia
Streptococcal sepsis (whole body inflammation by streptococcal)
Thrombocytosis

60+:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Confusional state
Depression
Diplopia (double vision)
Dizziness
Dry mouth
Dry skin
Dysphonia (speech disorder attributable to a disorder of phonation)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 20 people, 51.28%
Pain: 19 people, 48.72%
Gait Disturbance: 16 people, 41.03%
Urethritis Noninfective (inflammation of the urethra - non infective): 15 people, 38.46%
Blood Glucose Abnormal: 14 people, 35.90%
Diarrhea: 12 people, 30.77%
Bladder Disorder: 11 people, 28.21%
Itching: 10 people, 25.64%
Immunodeficiency Common Variable: 8 people, 20.51%
High Blood Pressure: 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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