Benzonatate and Narcan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Narcan (naloxone hydrochloride). Common drug interactions include major depression among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Narcan. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

On Aug, 03, 2026

82 people who take Benzonatate and Narcan together, and have interactions are studied.

Benzonatate and Narcan drug interactions.

What are the common drug interactions of Benzonatate and Narcan, by gender? *:

female:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Migraine (headache)
Multiple fractures
Neuralgia (pain in one or more nerves)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Post-traumatic stress disorder
Pyrexia (fever)
Renal tubular necrosis (death of kidney tubules)
Sinus congestion (blockage of sinus)

male:

Dyspnoea (difficult or laboured respiration)
Hand fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Renal impairment (severely reduced kidney function)
Abscess limb (limb infection)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bipolar disorder (mood disorder)
Chest pain
Death

What are the common drug interactions of Benzonatate and Narcan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Neoplasm malignant (cancer tumour)

30-39:

Renal failure (kidney dysfunction)
Hand fracture
Rib fracture
Neuropathy peripheral (surface nerve damage)
Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bone density decreased
Fibromyalgia (a long-term condition which causes pain all over the body)
Foot fracture
Mania (a state of abnormally elevated or irritable mood)

40-49:

Complications of transplanted heart
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Post procedural complication
Renal tubular necrosis (death of kidney tubules)
Arthralgia (joint pain)
Back pain
Fatigue (feeling of tiredness)
Joint stiffness

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abscess limb (limb infection)
Adenomatous polyposis coli ((fap) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine)
Colonic polyp (extra part of colon tissue grow in intestine)
Eye injury
Fall
Headache (pain in head)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Dyspnoea (difficult or laboured respiration)
Death
Fluid overload (too much fluid in the blood)
Hypotension (abnormally low blood pressure)
Oropharyngeal pain
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Renal failure (kidney dysfunction)
Sinus congestion (blockage of sinus)
Anion gap increased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 21 people, 25.61%
Pain: 20 people, 24.39%
High Blood Pressure: 17 people, 20.73%
Stress And Anxiety: 16 people, 19.51%
High Blood Cholesterol: 15 people, 18.29%
Diabetes: 14 people, 17.07%
Bipolar Disorder (mood disorder): 12 people, 14.63%
Depression: 12 people, 14.63%
Constipation: 11 people, 13.41%
Infection: 11 people, 13.41%

* Approximation only. Some reports may have incomplete information.

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