Benzonatate and Septra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Septra (sulfamethoxazole; trimethoprim). Common drug interactions include anxiety among females and upper gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Septra. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

On Jul, 06, 2026

24 people who take Benzonatate and Septra together, and have interactions are studied.

Benzonatate and Septra drug interactions.

What are the common drug interactions of Benzonatate and Septra, by gender? *:

female:

Anxiety
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Pain
Cholecystitis acute (rapid infection of gallbladder)
Dacryostenosis acquired (obstruction of the nasolacrimal duct-acquired)
Death
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)

male:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Bronchial hyperreactivity
Rash
Thrombocytopenia (decrease of platelets in blood)
Tremor (trembling or shaking movements in one or more parts of your body)
Activities of daily living impaired
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Ascites (accumulation of fluid in the abdominal cavity)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

What are the common drug interactions of Benzonatate and Septra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis acute (rapid infection of gallbladder)
Emotional distress
Injury

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Dyspepsia (indigestion)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Bronchial hyperreactivity
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Femur fracture

60+:

Asthenia (weakness)
Blood pressure decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hypoxia (low oxygen in tissues)
Immunodeficiency
Joint swelling
Lymphadenopathy (disease or enlargement of lymph nodes)
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 25.00%
Pain: 5 people, 20.83%
Nausea (feeling of having an urge to vomit): 5 people, 20.83%
Hiv Infection: 5 people, 20.83%
Multiple Myeloma (cancer of the plasma cells): 5 people, 20.83%
Adverse Event: 4 people, 16.67%
Inflammation: 3 people, 12.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 12.50%
Depression: 3 people, 12.50%
Diarrhea: 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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