Benzonatate and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Soliris (eculizumab). Common drug interactions include dizziness among females and cardiac death among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Soliris. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 18, 2026

14 people who take Benzonatate and Soliris together, and have interactions are studied.

Benzonatate and Soliris drug interactions.

What are the common drug interactions of Benzonatate and Soliris, by gender? *:

female:

  1. Dizziness
  2. Arthralgia (joint pain)
  3. Fatigue (feeling of tiredness)
  4. Foreign body in eye (foreign particle in eye)
  5. Full blood count decreased
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Iron overload
  8. Rash
  9. Anxiety
  10. Back pain

male:

  1. Cardiac death
  2. Ear infection
  3. Ear pain
  4. Fall
  5. Fatigue (feeling of tiredness)
  6. Hypoacusis (loss of hearing)
  7. Lower respiratory tract infection
  8. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  9. Nasopharyngitis (inflammation of the nasopharynx)
  10. Poor quality sleep

What are the common drug interactions of Benzonatate and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Blindness
  2. Blood glucose increased
  3. Cardiac failure congestive
  4. Fatigue (feeling of tiredness)
  5. Haemoglobin decreased
  6. Memory impairment
  7. Muscular weakness (muscle weakness)
  8. Nasopharyngitis (inflammation of the nasopharynx)

50-59:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Multi-organ failure (multisystem organ failure)

60+:

  1. Dizziness
  2. Fatigue (feeling of tiredness)
  3. Constipation
  4. Depression
  5. Dyspnoea (difficult or laboured respiration)
  6. Dyspnoea exertional (breathlessness or shortness of breath)
  7. Headache (pain in head)
  8. Incontinence (lack of moderation or self-control)
  9. Nausea (feeling of having an urge to vomit)
  10. Oedema (fluid collection in tissue)

What are the existing conditions these people have? *

  1. Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 7 people, 50.00%
  2. Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 5 people, 35.71%
  3. High Blood Pressure: 3 people, 21.43%
  4. Neuromyopathy (disease of both muscles and nerves): 2 people, 14.29%
  5. Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 14.29%
  6. Type 2 Diabetes: 1 person, 7.14%
  7. Stress And Anxiety: 1 person, 7.14%
  8. Rhinorrhea (watery mucus discharge from the nose): 1 person, 7.14%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Benzonatate and Soliris?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Benzonatate and Soliris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Benzonatate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Soliris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Benzonatate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Soliris and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on benzonatate and eculizumab (the active ingredients of Benzonatate and Soliris, respectively), and Benzonatate and Soliris (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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