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Bextra and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bextra (valdecoxib) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include asthenia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Bextra and Bactrim. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Jul, 27, 2026

85 people who take Bextra and Bactrim together, and have interactions are studied.

Bextra and Bactrim drug interactions.

What are the common drug interactions of Bextra and Bactrim, by gender? *:

female:

  1. Asthenia (weakness)
  2. Erythema (redness of the skin)
  3. Haematocrit decreased
  4. Haemoglobin decreased
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
  7. Dizziness
  8. Inflammation
  9. Purulent discharge (discharge that contains pus)
  10. Red blood cell count decreased

male:

  1. Fatigue (feeling of tiredness)
  2. Anaemia (lack of blood)
  3. Osteomyelitis (infection of bone)
  4. Abdominal pain
  5. Bone disorder
  6. Neuropathy peripheral (surface nerve damage)
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Abdominal distension
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Hypercholesterolaemia (high levels of cholesterol in the blood)

What are the common drug interactions of Bextra and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal pain
  2. Fatigue (feeling of tiredness)
  3. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  4. Liver disorder (liver diseases)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Pruritus (severe itching of the skin)
  7. Weight decreased

30-39:

  1. Renal failure acute (rapid kidney dysfunction)
  2. Asthenia (weakness)
  3. Difficulty in walking
  4. Muscle twitching
  5. Myalgia (muscle pain)
  6. Nausea (feeling of having an urge to vomit)
  7. Somnolence (a state of near-sleep, a strong desire for sleep)
  8. Vomiting
  9. Flushing (the warm, red condition of human skin)
  10. Arthralgia (joint pain)

40-49:

  1. Anaemia (lack of blood)
  2. Dyspnoea (difficult or laboured respiration)
  3. Anxiety
  4. Injury
  5. Osteomyelitis (infection of bone)
  6. Weight decreased
  7. Bone disorder
  8. Abdominal pain
  9. Hyperlipidaemia (presence of excess lipids in the blood)
  10. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

  1. Cough
  2. Deformity (disfigurement)
  3. Emotional distress
  4. Gait disturbance
  5. Oedema peripheral (superficial swelling)
  6. Tendonitis (a condition that causes pain and swelling of tendons)
  7. Abscess (pus)
  8. Anaemia (lack of blood)
  9. Arteriosclerosis (thickening and hardening of arteries)
  10. Arthritis (form of joint disorder that involves inflammation of one or more joints)

60+:

  1. Rash
  2. Cough
  3. Purulent discharge (discharge that contains pus)
  4. Red blood cell count decreased
  5. Asthenia (weakness)
  6. Dizziness
  7. Fatigue (feeling of tiredness)
  8. Chest pain
  9. Back pain
  10. Headache (pain in head)

What are the existing conditions these people have? *

  1. Depression: 18 people, 21.18%
  2. Insomnia (sleeplessness): 15 people, 17.65%
  3. Multiple Myeloma (cancer of the plasma cells): 14 people, 16.47%
  4. Breast Cancer: 13 people, 15.29%
  5. Metastases To Bone (cancer spreads to bone): 7 people, 8.24%
  6. High Blood Pressure: 7 people, 8.24%
  7. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 8.24%
  8. Joint Pain: 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Bextra and Bactrim?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Bextra and Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bextra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bextra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bactrim and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on valdecoxib and sulfamethoxazole; trimethoprim (the active ingredients of Bextra and Bactrim, respectively), and Bextra and Bactrim (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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