Bextra and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bextra (valdecoxib) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include vomiting among females and rib fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Bextra and Hydramine. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 15, 2026

43 people who take Bextra and Hydramine together, and have interactions are studied.

What are the common drug interactions of Bextra and Hydramine, by gender? *:

female:

Vomiting
Arthralgia (joint pain)
Abdominal pain upper
Chest pain
Drug ineffective
Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Weight decreased
Anxiety
Asthma

male:

Rib fracture
Dyspnoea (difficult or laboured respiration)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Fatigue (feeling of tiredness)
Fungal infection
Headache (pain in head)
Hepatic cyst
Hepatic steatosis (fatty liver disease)

What are the common drug interactions of Bextra and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain upper
Fatigue (feeling of tiredness)
Suicidal ideation
Weight decreased
Arthralgia (joint pain)
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Chest pain

20-29:

Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Adenoma benign (non-cancerous tumour -secreting)
Adnexa uteri cyst (ovarian cysts)
Allergic sinusitis
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic valve sclerosis (narrowing of the aortic valve)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

30-39:

Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chest injury
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysmenorrhoea (painful menstruation)
Essential hypertension (primary hypertension)
Excoriation (to tear or wear off the skin of)
Hypertension (high blood pressure)
Myalgia (muscle pain)

40-49:

Anxiety
Arthralgia (joint pain)
Asthma
Bone disorder
Bone pain
Cardiac failure congestive
Dental caries
Granuloma (a small area of inflammation due to tissue injury)
Injury
Neutropenia (an abnormally low number of neutrophils)

50-59:

Bipolar disorder (mood disorder)
Blood cholesterol increased
Blood glucose fluctuation
Blood glucose increased
Blood potassium decreased
Blood pressure increased
Blood sodium decreased
Blood triglycerides increased
Body height decreased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

60+:

Asthma
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Dermatitis allergic (inflammation of the skin due allergic reaction)
Drug ineffective
Fracture nonunion (permanent failure of healing following a broken bone)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lung disorder (lung disease)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 18.60%
Anaemia (lack of blood): 5 people, 11.63%
Stress And Anxiety: 4 people, 9.30%
Sleep Disorder: 4 people, 9.30%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 9.30%
Nausea (feeling of having an urge to vomit): 4 people, 9.30%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 9.30%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.30%
Weakness: 3 people, 6.98%
Headache (pain in head): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

Do you take Bextra and Hydramine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously