Bextra and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bextra (valdecoxib) and Hydrocortisone (hydrocortisone). Common drug interactions include formication among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Bextra and Hydrocortisone. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 12, 2026

39 people who take Bextra and Hydrocortisone together, and have interactions are studied.

Bextra and Hydrocortisone drug interactions.

What are the common drug interactions of Bextra and Hydrocortisone, by gender? *:

female:

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hyperlipidaemia (presence of excess lipids in the blood)
Injury
Inner ear disorder
International normalised ratio increased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Platelet count increased
Renal failure (kidney dysfunction)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Social avoidant behaviour (avoiding social connection a personality disorder)

male:

Hypotension (abnormally low blood pressure)
Rash pruritic (redness with itching)
Erythema multiforme (a type of hypersensitivity reaction)
Large intestinal ulcer
Malaise (a feeling of general discomfort or uneasiness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Mouth ulceration (mouth ulcers)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)

What are the common drug interactions of Bextra and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood cholesterol increased
Blood triglycerides increased
Obesity (having too much body fat)
Type 2 diabetes mellitus
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Erythema multiforme (a type of hypersensitivity reaction)

50-59:

Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Blood glucose decreased
Blood potassium decreased
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hyperlipidaemia (presence of excess lipids in the blood)
Injury
Inner ear disorder
International normalised ratio increased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Bladder neoplasm (bladder tumour)
Confusional state
Defaecation urgency (a sudden compelling urge to defecate)
Erythema multiforme (a type of hypersensitivity reaction)
Feeling jittery
Gallbladder operation
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Stress And Anxiety: 15 people, 38.46%
Restless Leg Syndrome (a powerful urge to move your legs): 15 people, 38.46%
Allergic Rhinitis: 12 people, 30.77%
High Blood Pressure: 12 people, 30.77%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 12 people, 30.77%
Panic Disorder: 12 people, 30.77%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 12 people, 30.77%
Ear Barotrauma (discomfort and possible damage in the ear due to pressure differences between the inside and outside of the eardrum): 12 people, 30.77%
Sinusitis (inflammation of sinus): 11 people, 28.21%
Depression: 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Bextra and Hydrocortisone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously