Bi-sifrol and Permax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bi-sifrol (pramipexole) and Permax (pergolide mesylate). Common drug interactions include road traffic accident among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Bi-sifrol and Permax. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Bi-sifrol?

Bi-sifrol has active ingredients of pramipexole. It is often used in restless leg syndrome. eHealthMe is studying from 729 Bi-sifrol users. Check the latest studies of Bi-sifrol.

What is Permax?

Permax has active ingredients of pergolide mesylate. eHealthMe is studying from 1,532 Permax users. Check the latest studies of Permax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

13 people who take Bi-sifrol and Permax together, and have interactions are studied.

What are the common drug interactions of Bi-Sifrol and Permax, by gender? *:

female:

Road traffic accident
Acute respiratory distress syndrome
Aphagia (inability or refusal to swallow)
Drug effect decreased
Dysphagia (a condition in which swallowing is difficult or painful)
Hydronephrosis (water inside the kidney)
Oral mucosal discolouration (change in colour of mucous membrane of mouth)
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Retroperitoneal fibrosis (a rare disorder that occurs when extra fibrous tissue forms in the area behind the stomach and intestines)

male:

Abnormal behaviour
Hallucination, visual (seeing things that aren't there)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Automatism (performance of actions without conscious thought or intention)
Communication disorder (speech and language disorder)
Hypersexuality
Pathological gambling
Somnolence (a state of near-sleep, a strong desire for sleep)
Sudden onset of sleep
Depression

What are the common drug interactions of Bi-Sifrol and Permax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Acute respiratory distress syndrome
Aphagia (inability or refusal to swallow)
Drug effect decreased
Hydronephrosis (water inside the kidney)
Pneumonia
Retroperitoneal fibrosis (a rare disorder that occurs when extra fibrous tissue forms in the area behind the stomach and intestines)
Ureteric obstruction

60+:

Abnormal behaviour
Hallucination, visual (seeing things that aren't there)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sudden onset of sleep
Road traffic accident
Pleural effusion (water on the lungs)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Dysphagia (a condition in which swallowing is difficult or painful)
Oral mucosal discolouration (change in colour of mucous membrane of mouth)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

What are the existing conditions these people have? *

Parkinson's Disease: 13 people, 100.00%
Gastritis (inflammation of stomach): 3 people, 23.08%
Constipation: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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