Biaxin and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Biaxin (clarithromycin) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include dizziness among females and anal abscess among males.

The phase IV clinical study analyzes what interactions people have when they take Biaxin and Macrobid. It is created by eHealthMe based on reports of 99 people who take the same drugs from the FDA, and is updated regularly.

What is Biaxin?

Biaxin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 14,248 Biaxin users. Check the latest studies of Biaxin.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

99 people who take Biaxin and Macrobid together, and have interactions are studied.

What are the common drug interactions of Biaxin and Macrobid, by gender? *:

female:

Dizziness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Optic atrophy (the loss of a proportion of optic disc nerve fibres)
Headache (pain in head)
Fall
Tardive dyskinesia (a disorder that involves involuntary movements)
Dysphagia (a condition in which swallowing is difficult or painful)
Deformity (disfigurement)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

male:

Anal abscess
Cellulitis (infection under the skin)
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Scrotal abscess (pus in scrotum)
Scrotal oedema (swelling of scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Testicular necrosis (damaged testes)

What are the common drug interactions of Biaxin and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal weight gain
Adverse reaction
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cataract (clouding of the lens inside the eye)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Device expulsion
Drug intolerance (drug sensitivity)

20-29:

Headache (pain in head)
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Actinomyces test positive
Acute psychosis (period of mentally unstable behaviour)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Bone disorder
Breath odour
Candidiasis (candidiasis or thrush is a fungal infection)

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypertension (high blood pressure)
Intra-uterine death
Anal abscess
Back pain
Breast cyst
Cellulitis (infection under the skin)
Drug hypersensitivity
Dyslipidaemia (abnormal amount of lipids)

40-49:

Upper respiratory tract infection
Renal failure (kidney dysfunction)
Nausea (feeling of having an urge to vomit)
Restless legs syndrome (a powerful urge to move your legs)
Body temperature increased
Chronic kidney disease
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug hypersensitivity

50-59:

Renal failure (kidney dysfunction)
Ankle fracture
Anxiety disorder
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)
Back pain
Blood glucose decreased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Contusion (a type of hematoma of tissue in which capillaries)

60+:

Dysphagia (a condition in which swallowing is difficult or painful)
Pain
Rhinalgia (pain in the nose)
Sensation of foreign body
Tinnitus (a ringing in the ears)
Balance disorder
Blindness
Drug hypersensitivity
Neck pain
Nervous system disorder (a general class of medical conditions affecting the nervous system)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 24 people, 24.24%
Pain: 12 people, 12.12%
Oedema (fluid collection in tissue): 12 people, 12.12%
Pneumonia: 10 people, 10.10%
Fever: 9 people, 9.09%
High Blood Cholesterol: 9 people, 9.09%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 8.08%
Respiratory Tract Infection: 8 people, 8.08%
Renal Cell Carcinoma (a kidney cancer): 8 people, 8.08%
Psychotic Disorder: 8 people, 8.08%

* Approximation only. Some reports may have incomplete information.

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