Bifidobacterium and Topiramate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bifidobacterium (bifidobacteria) and Topiramate (topiramate). Common drug interactions include muscular weakness among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Bifidobacterium and Topiramate. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Bifidobacterium?

Bifidobacterium has active ingredients of bifidobacteria. eHealthMe is studying from 5,013 Bifidobacterium users. Check the latest studies of Bifidobacterium.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

56 people who take Bifidobacterium and Topiramate together, and have interactions are studied.

Bifidobacterium and Topiramate drug interactions.

What are the common drug interactions of Bifidobacterium and Topiramate, by gender? *:

female:

Muscular weakness (muscle weakness)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Neck pain
Nerve block (the interruption of signals travelling along a nerve)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Procedural pain
Respiratory depression (respiration has a rate below 12 breaths)

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Infection
Insomnia (sleeplessness)
Nasopharyngitis (inflammation of the nasopharynx)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Sleep disorder
Sleep-related eating disorder (abnormal eating patterns during the night)

What are the common drug interactions of Bifidobacterium and Topiramate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Glossoptosis
Respiratory depression (respiration has a rate below 12 breaths)
Secretion discharge

10-19:

Angiopathy (generic term for a disease of the blood vessels)
Loss of consciousness
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Sinusitis (inflammation of sinus)

20-29:

Hyperammonaemia
Near drowning (means a person almost died from not being able to breathe under water)
Liver disorder (liver diseases)

30-39:

Arthralgia (joint pain)
Breast cancer
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Injection site pain
Injection site urticaria (rash of round, red welts on the skin at injection site)
Nasopharyngitis (inflammation of the nasopharynx)
Secretion discharge
Surgery
Weight fluctuation

40-49:

Eyelid ptosis (falling of the upper or lower eyelid)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Lacrimation increased
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Visual impairment
Asthma
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Heart rate irregular

50-59:

Addison's disease (addison's disease, a hormonal disorder disease)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Ear infection
Gastric ulcer (stomach ulcer)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infection
Influenza like illness

60+:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Chronic kidney disease
Oedema peripheral (superficial swelling)
Rash
Rash erythematous (redness of the skin)
Rash pruritic (redness with itching)
Renal failure (kidney dysfunction)
Erythema of eyelid (redness of the eyelid)
Eye disorder
Infection

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 17.86%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 14.29%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 10.71%
Asthma: 6 people, 10.71%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 8.93%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 5 people, 8.93%
Encephalitis (inflammation of the brain): 5 people, 8.93%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 8.93%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 7.14%
Drowsiness: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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