Biktarvy and Norco drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Biktarvy (bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate) and Norco (acetaminophen; hydrocodone bitartrate). Common drug interactions include general physical health deterioration among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Biktarvy and Norco. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Biktarvy?

Biktarvy has active ingredients of bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 19,543 Biktarvy users. Check the latest studies of Biktarvy.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

On Jul, 31, 2026

45 people who take Biktarvy and Norco together, and have interactions are studied.

What are the common drug interactions of Biktarvy and Norco, by gender? *:

female:

General physical health deterioration (weak health status)
Hip fracture
Injury
Insomnia (sleeplessness)
Lower limb fracture
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Protein urine present
Quality of life decreased
Renal impairment (severely reduced kidney function)

male:

Emotional distress
Anxiety
Bone loss
Blood creatinine increased
Diarrhoea
Hypokalaemia (low potassium)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal impairment (severely reduced kidney function)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Decreased activity

What are the common drug interactions of Biktarvy and Norco, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Chronic kidney disease
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Tooth extraction
Arthralgia (joint pain)
Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone pain

30-39:

Bone density decreased
Emotional distress
Foot fracture
Hand fracture
Intervertebral disc degeneration (spinal disc degeneration)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Tooth loss

40-49:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Osteonecrosis (death of bone)
Renal impairment (severely reduced kidney function)
Bone density decreased
Tooth loss
Blood creatinine increased
Hip arthroplasty

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Emotional distress
Anxiety
Bone density decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Hypokalaemia (low potassium)
Osteonecrosis (death of bone)
Tooth loss
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)

60+:

Emotional distress
Bone density decreased
Abdominal discomfort
Bone fragmentation
Death
Diarrhoea
Hip fracture
Impaired healing
Insomnia (sleeplessness)
Mouth ulceration (mouth ulcers)

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 8.89%
High Blood Cholesterol: 4 people, 8.89%
Depression: 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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