Biktarvy and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Biktarvy (bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate) and Phenergan (promethazine hydrochloride). Common drug interactions include anxiety among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Biktarvy and Phenergan. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Biktarvy?

Biktarvy has active ingredients of bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 19,543 Biktarvy users. Check the latest studies of Biktarvy.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Aug, 13, 2026

18 people who take Biktarvy and Phenergan together, and have interactions are studied.

Biktarvy and Phenergan drug interactions.

What are the common drug interactions of Biktarvy and Phenergan, by gender? *:

female:

Anxiety
Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Osteoporosis (bones weak and more likely to break)
Back pain
Bone density decreased
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Depression
Pain in extremity

male:

Emotional distress
Pain
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Nephrolithiasis (calculi in the kidneys)
Osteonecrosis (death of bone)
Proteinuria (presence of protein in the urine)
Renal disorder (kidney disease)
Arthralgia (joint pain)
Foot fracture

What are the common drug interactions of Biktarvy and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Bone density decreased
Decreased activity
Emotional distress
Facial bones fracture (bone fracture of face)
Jaw fracture
Osteoporosis (bones weak and more likely to break)
Pain

30-39:

Bone density decreased
Emotional distress
Pain
Anxiety
Arthralgia (joint pain)
Depression
Foot fracture
Hand fracture
Intervertebral disc degeneration (spinal disc degeneration)
Osteonecrosis (death of bone)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal impairment (severely reduced kidney function)
Bone density decreased
Chronic kidney disease
Proteinuria (presence of protein in the urine)
Renal disorder (kidney disease)
Tooth loss

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Salivary hypersecretion (excess saliva secretion)
Somnolence (a state of near-sleep, a strong desire for sleep)
Back pain
Bone density decreased
Bone loss

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Pain
Pain in extremity
Pain in jaw
Quality of life decreased
Rib fracture
Spinal fracture (fracture in one of vertebrae)
Arthralgia (joint pain)
Back pain

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 22.22%
High Blood Pressure: 4 people, 22.22%
Hypersensitivity: 3 people, 16.67%
Pain: 3 people, 16.67%
High Blood Cholesterol: 3 people, 16.67%
Rickets (softening of bones): 2 people, 11.11%
Prostatic Disorder: 2 people, 11.11%
Stress And Anxiety: 2 people, 11.11%
Infection: 2 people, 11.11%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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