Botox cosmetic and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Botox cosmetic (botulinum toxin type a) and Melatonin (melatonin). Common drug interactions include cluster headache among females and alopecia among males.

The phase IV clinical study analyzes what interactions people have when they take Botox cosmetic and Melatonin. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Botox cosmetic?

Botox cosmetic has active ingredients of botulinum toxin type a. It is often used in wrinkles. eHealthMe is studying from 37,851 Botox cosmetic users. Check the latest studies of Botox cosmetic.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 20, 2026

30 people who take Botox cosmetic and Melatonin together, and have interactions are studied.

Botox cosmetic and Melatonin drug interactions.

What are the common drug interactions of Botox Cosmetic and Melatonin, by gender? *:

female:

Cluster headache (one-sided head pain with tearing)
Cough
Diplopia (double vision)
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Gait disturbance
Heart rate decreased
Heart rate increased
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)

male:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Disturbance in attention
Dry eye (lack of adequate tears)
Dry mouth
Fibromyalgia (a long-term condition which causes pain all over the body)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Hypoaesthesia (reduced sense of touch or sensation)
Hypotonia (low muscle tone)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)

What are the common drug interactions of Botox Cosmetic and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Discomfort
Dizziness
Drug hypersensitivity
Fatigue (feeling of tiredness)
Feeling cold
Feeling drunk
Hallucination (an experience involving the perception of something not present)
Hyperacusis (disorder in loudness perception)
Migraine (headache)

30-39:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Photophobia (extreme sensitivity to light)
Presyncope
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Skin tightness
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tinnitus (a ringing in the ears)
Tremor (trembling or shaking movements in one or more parts of your body)

40-49:

Asthenia (weakness)
Dizziness
Drug ineffective
Enuresis (repeated inability to control urination)
Euphoric mood (excessively happy but may become angry or irritable)
Influenza
Myalgia (muscle pain)
Nasal septum deviation (deviated nasal septum)
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Skin exfoliation (removal of the oldest dead skin cells)

50-59:

n/a

60+:

Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Swelling
Tenderness (pain or discomfort when an affected area is touched)

What are the existing conditions these people have? *

Skin Wrinkling (wrinkle on skin): 17 people, 56.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 43.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 30.00%
Sleep Disorder: 7 people, 23.33%
Rashes (redness): 2 people, 6.67%
Bipolar Disorder (mood disorder): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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