Botox and Aciphex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Botox (botulinum toxin type a) and Aciphex (rabeprazole sodium). Common drug interactions include disease recurrence among females and diabetes mellitus inadequate control among males.

The phase IV clinical study analyzes what interactions people have when they take Botox and Aciphex. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

On Aug, 13, 2026

35 people who take Botox and Aciphex together, and have interactions are studied.

What are the common drug interactions of Botox and Aciphex, by gender? *:

female:

Disease recurrence
Dizziness postural
Drug administration error
Drug hypersensitivity
Dry mouth
Dyspepsia (indigestion)
Dystonia (abnormal muscle tone)
Eating disorder
Fall
Muscular weakness (muscle weakness)

male:

Diabetes mellitus inadequate control
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Vision blurred
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysphagia (a condition in which swallowing is difficult or painful)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Muscular weakness (muscle weakness)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)

What are the common drug interactions of Botox and Aciphex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus inadequate control
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Type 1 diabetes mellitus
Type 2 diabetes mellitus

40-49:

Headache (pain in head)
Vision blurred
Asthenia (weakness)
Burning sensation
Chest discomfort
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

50-59:

Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood cholesterol increased
Blood triglycerides increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Liver injury
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)

60+:

Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Muscular weakness (muscle weakness)
Activities of daily living impaired
Adverse event
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Asthenia (weakness)
Back pain
Balance disorder

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 17.14%
Pain: 6 people, 17.14%
Depression: 6 people, 17.14%
Skin Wrinkling (wrinkle on skin): 5 people, 14.29%
Muscle Spasms (muscle contraction): 5 people, 14.29%
Sleep Disorder: 4 people, 11.43%
Asthma: 4 people, 11.43%
Nausea (feeling of having an urge to vomit): 4 people, 11.43%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 4 people, 11.43%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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