Botox and Dexedrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Botox (botulinum toxin type a) and Dexedrine (dextroamphetamine sulfate). Common drug interactions include therapeutic response decreased among females and craniocerebral injury among males.

The phase IV clinical study analyzes what interactions people have when they take Botox and Dexedrine. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

What is Dexedrine?

Dexedrine has active ingredients of dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,735 Dexedrine users. Check the latest studies of Dexedrine.

On Jul, 05, 2026

38 people who take Botox and Dexedrine together, and have interactions are studied.

What are the common drug interactions of Botox and Dexedrine, by gender? *:

female:

Therapeutic response decreased (less preventive response)
Headache (pain in head)
Drug ineffective
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Muscle spasms (muscle contraction)
Rash
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hypertension (high blood pressure)
Abdominal pain upper
Blepharospasm (any abnormal contraction or twitch of the eyelid)

male:

Craniocerebral injury (injury to cranium and brain)
Hypersomnia (excessive daytime sleepiness (eds))
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pain
Stress
Surgery
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood testosterone decreased
Fall
Haemorrhage (bleeding)

What are the common drug interactions of Botox and Dexedrine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Increased appetite
Muscle disorder (muscle disease)
Muscle spasms (muscle contraction)
Pain
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Rash
Therapeutic response decreased (less preventive response)
Weight increased

30-39:

n/a

40-49:

Asthenia (weakness)
Cerebral haemorrhage (bleeding within the brain)
Deep brain stimulation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Hunger
Loss of consciousness

50-59:

Therapeutic response decreased (less preventive response)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Joint injury
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Dehydration (dryness resulting from the removal of water)
Hospitalisation
Hypertension (high blood pressure)
Immune system disorder
Surgery
Drug ineffective

60+:

Anxiety
Drug ineffective
Hot flush (sudden feelings of heat)
Hypertension (high blood pressure)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Renal disorder (kidney disease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 34 people, 89.47%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 27 people, 71.05%
Drowsiness: 10 people, 26.32%
Rashes (redness): 3 people, 7.89%
Neuralgia (pain in one or more nerves): 3 people, 7.89%
Abdominal Pain Upper: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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