Brethine and Coumadin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brethine (terbutaline sulfate) and Coumadin (warfarin sodium). Common drug interactions include dilatation ventricular among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Brethine and Coumadin. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Brethine?

Brethine has active ingredients of terbutaline sulfate. eHealthMe is studying from 480 Brethine users. Check the latest studies of Brethine.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.



On Jul, 16, 2026

14 people who take Brethine and Coumadin together, and have interactions are studied.

Brethine and Coumadin drug interactions.

What are the common drug interactions of Brethine and Coumadin, by gender? *:

female:

  1. Dilatation ventricular
  2. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  3. Dyspepsia (indigestion)
  4. Dysuria (painful or difficult urination)
  5. Electrocardiogram st-t change
  6. Erythema (redness of the skin)
  7. Failure to thrive (inadequate weight gain and physical growth in children)
  8. Fall
  9. Feeling hot
  10. Flatulence (flatus expelled through the anus)

male:

  1. Acute respiratory failure
  2. Pain
  3. Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
  4. Sweating increased (excess sweating)
  5. Atrioventricular block (heart block)
  6. Blood carbon dioxide increased
  7. Blood cholesterol increased
  8. Blood ph decreased
  9. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  10. Cholecystitis acute (rapid infection of gallbladder)

What are the common drug interactions of Brethine and Coumadin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Abdominal pain
  2. Blood bicarbonate decreased
  3. Diabetes mellitus inadequate control
  4. Diarrhoea
  5. Dyspnoea (difficult or laboured respiration)
  6. Dysuria (painful or difficult urination)
  7. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  8. Heart rate decreased
  9. Impaired gastric emptying
  10. Infusion related reaction

50-59:

  1. Sweating increased (excess sweating)
  2. Atrioventricular block (heart block)
  3. Blood carbon dioxide increased
  4. Blood ph decreased
  5. Cholecystitis acute (rapid infection of gallbladder)
  6. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  7. Cough
  8. Po2 increased
  9. Pyrexia (fever)
  10. Sinusitis (inflammation of sinus)

60+:

  1. Blood pressure decreased
  2. Blood sodium decreased
  3. Blood cholesterol increased
  4. Blood potassium increased
  5. Blood urea increased
  6. Cardioactive drug level increased
  7. Cardiomyopathy (weakening of the heart muscle)
  8. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  9. Corneal opacity (scarring or clouding of the cornea)
  10. Dizziness

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 21.43%
  2. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 21.43%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 14.29%
  4. Fungal Nail Infection: 1 person, 7.14%
  5. Depression: 1 person, 7.14%
  6. Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 1 person, 7.14%
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Brethine and Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Brethine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Brethine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Coumadin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on terbutaline sulfate and warfarin sodium (the active ingredients of Brethine and Coumadin, respectively), and Brethine and Coumadin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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