Brethine and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brethine (terbutaline sulfate) and Reglan (metoclopramide hydrochloride). Common drug interactions include dyspnoea among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Brethine and Reglan. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Brethine?

Brethine has active ingredients of terbutaline sulfate. eHealthMe is studying from 480 Brethine users. Check the latest studies of Brethine.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.



On Jul, 20, 2026

23 people who take Brethine and Reglan together, and have interactions are studied.

Brethine and Reglan drug interactions.

What are the common drug interactions of Brethine and Reglan, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Oxygen saturation decreased
  3. Aortic valve incompetence
  4. Apnoea (suspension of external breathing)
  5. Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
  6. Atelectasis (partial or complete collapse of the lung)
  7. Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
  8. Cardiac arrest
  9. Cardiac murmur (an heart sound in valve abnormality)
  10. Cardiomegaly (increased size of heart than normal)

male:

  1. Anxiety
  2. Drug exposure during pregnancy
  3. Brain neoplasm (tumour of brain)
  4. Chylothorax (collection of lymph fluid around the lung)
  5. Feeding disorder neonatal (when newborn refuse to drink milk)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Weight decreased
  8. Body temperature fluctuation
  9. Jaundice neonatal (yellowing of skin in neonate)
  10. Cardiac failure congestive

What are the common drug interactions of Brethine and Reglan, by age (0-1 to 60+)? *:

0-1:

  1. Brachial plexus injury (brachial plexus injuries, are caused by damage to those nerves network that conducts signals from the spinal cord)
  2. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  3. Cyst (a closed sac)
  4. Developmental delay
  5. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  6. Hyperbilirubinaemia neonatal (excess of bilirubin in the blood in newborn)
  7. Hypotonia neonatal (low muscle tone in neonatal)
  8. Jaundice neonatal (yellowing of skin in neonate)
  9. Laryngeal disorder (disease of larynx related to voice)
  10. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chest pain
  2. Complications of maternal exposure to therapeutic drugs
  3. Dependence
  4. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  5. Dyspnoea (difficult or laboured respiration)
  6. Headache (pain in head)
  7. Heart rate increased
  8. Palpitations (feelings or sensations that your heart is pounding or racing)
  9. Pregnancy
  10. Premature labour

40-49:

  1. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  2. Heart rate decreased
  3. Impaired gastric emptying
  4. Infusion related reaction
  5. Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
  6. Lupus pneumonitis (a chronic inflammatory autoimmune disorder that may affect lung)
  7. Melaena (the passage of black, tarry stools)
  8. Oxygen saturation decreased
  9. Pco2 decreased
  10. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

50-59:

n/a

60+:

  1. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  2. Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
  3. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 12 people, 52.17%
  2. Stress And Anxiety: 10 people, 43.48%
  3. Ill-Defined Disorder: 7 people, 30.43%
  4. Blood Disorder: 7 people, 30.43%
  5. Migraine (headache): 6 people, 26.09%
  6. Premature Labor: 3 people, 13.04%
  7. Urinary Tract Infection: 2 people, 8.70%
  8. Nausea And Vomiting: 2 people, 8.70%
  9. Depression: 2 people, 8.70%
  10. Candidiasis (candidiasis or thrush is a fungal infection): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Brethine and Reglan?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Brethine and Reglan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Brethine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Reglan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Brethine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Reglan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on terbutaline sulfate and metoclopramide hydrochloride (the active ingredients of Brethine and Reglan, respectively), and Brethine and Reglan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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